Patients with heart disease who take cholesterol-lowering statins are less likely to develop depression than those who don’t, according to new research.
Mary Whooley, MD, a physician at the San Francisco VA Medical Center and a professor of medicine at the University of California, San Francisco, evaluated 965 heart disease patients for depression, and found that those on statins were significantly less likely to be clinically depressed than those who were not on the drugs.
The researchers then followed the 776 patients who were not depressed — 520 who were using statins and 256 who were not — for an additional six years. Of those taking statins, 18.5 percent developed depression, compared with 28 percent of those not on the drugs. The patients who took statins were 38 percent less likely to develop depression than patients who did not, the researchers note.
As the study went on, said Whooley, the difference between the two groups became more pronounced, with the patients on statins becoming less likely to develop depression and the patients not on statins becoming more likely to become depressed.
“This would suggest that statins may have some kind of long-term protective effect against depression, perhaps by helping to prevent atherosclerosis in the brain, which can contribute to depressive symptoms,” Whooley said.
She also noted that statins have positive effects on the endothelium — the inner lining of the blood vessels — keeping blood vessels less rigid and better able to adapt to the body’s changing needs. “The exact mechanism is not known, however, and requires further study,” she said.
Whooley cautioned that it is possible that patients who take statins “are just healthier overall than those who don’t, and somehow we’re not accounting for that in our analysis, even though we adjusted for factors such as smoking, physical activity and cholesterol levels.”
If statins are definitively proven to protect against depression, said Whooley, they could be used to reduce the burden of depressive symptoms in patients with heart disease and, by extension, improve cardiovascular outcomes in depressed patients. Whooley has shown in previous studies that heart disease patients with depression are less likely to exercise and take medication, increasing their risk for heart attack, stroke, and other cardiovascular events.
The study was published in the Journal of Clinical Psychiatry.