Multiple exposures to anesthesia at a young age are associated with higher rates of attention deficit hyperactivity disorder (ADHD), according to researchers at the Mayo Clinic.
Children exposed to two or more anesthetics before age 3 had more than double the incidence of ADHD than children who had no exposure, says David Warner, M.D., a Mayo Clinic pediatric anesthesiologist and investigator on the observational study.
The researchers’ interest was piqued when studies began to suggest anesthesia used in surgery causes changes in the brains of young animals, Warner says.
“We were skeptical that the findings in animals would correlate with kids, but it appears that it does,” he notes.
The new study examined results of an existing epidemiological study that looked at the educational records of children born between 1976 and 1982 in Rochester, Minn., and determined those who developed some form of learning disability or ADHD.
Among 341 cases of ADHD in those younger than 19, researchers traced medical records in the Rochester Epidemiology Project, a decades-long database of all patient care in Olmsted County, Minn., looking for exposure to anesthesia and surgery before age 3.
What they found is that children who had no exposure to anesthesia and surgery had ADHD at a rate of 7.3 percent. The rate after a single exposure to anesthesia and surgery was approximately the same.
But for children who had two or more exposures to anesthesia and surgery, the rate of ADHD was 17.9 percent — even after researchers adjusted for other factors, including gestational age, sex, birth weight, and other health conditions.
The results of the study, however, do not mean that anesthesia causes attention deficit disorder, Warner says.
“This is an observational study,” he says. “A wide range of other factors might be responsible for the higher frequency of ADHD in children with multiple exposures. The findings certainly do suggest that further investigation into this area is warranted, and investigators at Mayo Clinic and elsewhere are actively pursuing these studies.”
Source: Mayo Clinic