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Low Vitamin B12 Tied to Memory, Cognition Problems

Low Vitamin B12 Tied to Memory, Cognition Problems A new study suggests low blood levels of vitamin B12 markers in older adults may be associated with lower brain volumes and problems with cognition.

Researchers at Rush University Medical Center say that foods from animals, including fish, meat, especially liver, milk, eggs and poultry are usual sources of vitamin B12.

Investigators took blood samples from 121 older residents of the South Side of Chicago who are a part of the Chicago Health and Aging Project (CHAP) — a large study of 10,000 biracial subjects over the age of 65.

The results of the study are published in Neurology, the medical journal of the American Academy of Neurology.

The participants had blood drawn to measure levels of vitamin B12 and B12-related markers that can indicate a B12 deficiency. The same subjects took tests measuring their memory and other cognitive skills.

After about 4 1/2 years, MRI scans of the participants’ brains were taken to measure total brain volume and look for other signs of brain damage.

Researchers determined vitamin B12 deficiency was associated with having lower scores on the cognitive tests and smaller total brain volume.

“Our findings definitely deserve further examination,” said Christine C. Tangney, Ph.D., associate professor in the department of clinical nutrition at Rush University Medical Center, and lead author of the study.

“It’s too early to say whether increasing vitamin B12 levels in older people through diet or supplements could prevent these problems, but it is an interesting question to explore. Findings from a British trial with B vitamin supplementation are also supportive of these outcomes.”

Tangney noted that the level of vitamin B12 itself in the blood was not associated with cognitive problems or loss in brain volume. She said that low vitamin B12 can be difficult to detect in older people when looking only at blood levels of the vitamin.

“Our findings lend support for the contention that poor vitamin B12 status is a potential risk factor for brain atrophy and may contribute to cognitive impairment,” said Tangney.

Source: Rush University Medical Center

Low Vitamin B12 Tied to Memory, Cognition Problems

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Low Vitamin B12 Tied to Memory, Cognition Problems. Psych Central. Retrieved on January 22, 2019, from
Scientifically Reviewed
Last updated: 8 Aug 2018
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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