Emerging research suggests nicotine receptors play an important role in social interaction and the ability to choose between competing motivations.

In the new research, scientists from France show that the nicotinic receptors in the prefrontal cortex are essential for social interaction in mice and that this area of the brain is necessary for adapted and balanced social interactions to occur.

Experts believe this this new knowledge could eventually lead to new treatments for ADHD, schizophrenia, and depression, among other illnesses.

To make this discovery, Sylvie Granon and colleagues introduced mice into an open space and tested their will to interact with other mice of the same sex or to explore a novel place.
The respective times spent for either social contact or novelty exploration were measured and quantitatively evaluated.

Researchers then removed the prefrontal cortex in otherwise normal mice, which resulted in mice with significant social deficits. Those genetically modified to lack the nicotinic receptor gene for a widespread subunit called beta2 subtype, seemed to favor social contact rather than the investigation of a novel environment.

When the beta2 nicotinic receptor in the brain was re-expressed, a normal balance between social contact and novelty seeking was restored.

Researchers say the findings show that there is a biological explanation for social interaction.

“This research can be summed up by saying that it’s the real-life equivalent of Chatty Cathy marrying the Marlboro Man,” said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal.

“Who could have guessed that there may be a biological explanation for ‘social butterflies.’ The explanation was found in an area of the brain that for decades has been considered a locus for nicotine addiction.”

Source: Federation of American Societies for Experimental Biology