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Possible Genetic Link Identified for Schizophrenia

An international study has determined a risk gene for schizophrenia.

Using genome-wide association data-mining techniques and independent replications, the team also discovered the mutation that begins the process.

The results of the research, led by Xiangning Chen, Ph.D is reported in the September issue of the journal Molecular Psychiatry.

In recent years, scientists have used genome-wide association studies to identify possible candidate genes responsible for diseases that include type 2 diabetes, lung cancer, Parkinson’s disease, rheumatoid arthritis and systemic lupus erythematosus.

However, the same approach was not as successful for the study of schizophrenia.

According to Chen, one of the many possible reasons is that many genes are involved in schizophrenia and the effect of each individual gene is relatively small.

For this reason, he said, results obtained from individual samples tend to fluctuate.

Chen said that to obtain consistent results researchers need to consider the results from many independent samples.

The team used that approach in this study by first screening two genome-wide association datasets with statistic, genomic, informatic and genetic data and then ranking the top candidate. Chen said that the selected candidates were verified by more than 20 independent samples.

According to Chen, the work is one of the largest genetic studies of schizophrenia and included more than 33,000 participants that identify cardiomyopathy associated 5, or CMYA5, as a risk gene for schizophrenia.

Its function is unknown at this time.

“While its implication for patient care is not clear at this moment, it is fair to say that our paper provides a new target for future research and a practical method to identify other potential risk genes. The findings are one of the most consistent findings in recent literature,” said Chen.

Source: Virginia Commonwealth University

Possible Genetic Link Identified for Schizophrenia

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Possible Genetic Link Identified for Schizophrenia. Psych Central. Retrieved on July 15, 2018, from https://psychcentral.com/news/2010/09/15/possible-genetic-link-identified-for-schizophrenia/18160.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.