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Can Psychological Trauma Be Inherited?

An emerging topic of investigation looks to determine if post-traumatic stress disorder (PTSD) can be passed to subsequent generations.

Scientists are studying groups with high rates of PTSD, such as the survivors of the Nazi death camps. Adjustment problems of the children of the survivors — the so-called “second generation” — is topic of study for researchers.

Studies suggested that some symptoms or personality traits associated with PTSD may be more common in the second generation than the general population.

It has been assumed that these transgenerational effects reflected the impact of PTSD upon the parent-child relationship rather than a trait passed biologically from parent to child.

However, Dr. Isabelle Mansuy and colleagues provide new evidence in the current issue of Biological Psychiatry that some aspects of the impact of trauma cross generations and are associated with epigenetic changes, i.e., the regulation of the pattern of gene expression, without changing the DNA sequence.

They found that early-life stress induced depressive-like behaviors and altered behavioral responses to aversive environments in mice.

Importantly, these behavioral alterations were also found in the offspring of males subjected to early stress even though the offspring were raised normally without any stress. In parallel, the profile of DNA methylation was altered in several genes in the germline (sperm) of the fathers, and in the brain and germline of their offspring.

“It is fascinating that clinical observations in humans have suggested the possibility that specific traits acquired during life and influenced by environmental factors may be transmitted across generations. It is even more challenging to think that when related to behavioral alterations, these traits could explain some psychiatric conditions in families,” said Dr. Mansuy.

“Our findings in mice provide a first step in this direction and suggest the intervention of epigenetic processes in such phenomenon.”

“The idea that traumatic stress responses may alter the regulation of genes in the germline cells in males means that these stress effects may be passed across generations. It is distressing to think that the negative consequences of exposure to horrible life events could cross generations,” commented Dr. John Krystal, editor of Biological Psychiatry.

“However, one could imagine that these types of responses might prepare the offspring to cope with hostile environments. Further, if environmental events can produce negative effects, one wonders whether the opposite pattern of DNA methylation emerges when offspring are reared in supportive environments.”

Source: Elsevier

Can Psychological Trauma Be Inherited?

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Can Psychological Trauma Be Inherited?. Psych Central. Retrieved on July 16, 2018, from https://psychcentral.com/news/2010/09/09/can-psychological-trauma-be-inherited/17901.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.