Hair as Biomarker of Stress and Heart DiseaseNew research provides the first evidence that a biomarker can be used to measure chronic stress and its relationship to heart attacks.

Stressors such as job, marital and financial problems have been linked to the increased risk for developing cardiovascular disease including heart attack. But there hasn’t been a biological marker to measure chronic stress.

To address this need, Drs. Gideon Koren and Stan Van Uum from The University of Western Ontario developed a method to measure cortisol levels in hair.

Cortisol is considered to be a stress hormone. Its secretion is increased during times of stress.

Traditionally it’s been measured in serum, urine and saliva, but that only shows stress at the time of measurement, not over longer periods of time. Cortisol is also captured in the hair shaft.

Koren and Uum believe hair analysis can provide an accurate assessment of stress levels in the months prior to an acute event such as a heart attack.

The research is published online in the journal Stress.

“Intuitively we know stress is not good for you, but it’s not easy to measure,” explains Dr. Koren, at Western’s Schulich School of Medicine & Dentistry.

“We know that on average, hair grows one centimetre (cm) a month, and so if we take a hair sample six cm long, we can determine stress levels for six months by measuring the cortisol level in the hair.”

In the study, hair samples three cm long were collected from 56 male adults who were admitted to the Meir Medical Centre in Kfar-Saba, Israel suffering heart attacks.

A control group, made up of 56 male patients who were hospitalized for reasons other than a heart attack, was also asked for hair samples. Higher hair cortisol levels corresponding to the previous three months were found in the heart attack patients compared to the control group.

The prevalence of diabetes, hypertension, smoking and family history of coronary artery disease did not differ significantly between the two groups, although the heart attack group had more cholesterol problems. After accounting for the known risk factors, hair cortisol content emerged as the strongest predictor of heart attack.

“Stress is a serious part of modern life affecting many areas of health and life,” says Dr. Koren.

“This study has implications for research and for practice, as stress can be managed with lifestyle changes and psychotherapy.”

Source: University of Western Ontario