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Mania Increases Risk for Cardiovascular Illness

People with a history of manic or hypomanic episodes have an increased risk for cardiovascular disease (CVD), a Johns Hopkins University study suggests.

“Recognition of manic symptoms and addressing related CVD risk factors could have long-term preventative implications in the development of CVD in the community,” according to Christine Ramsey and colleagues at the university.

While bipolar disorder previously has been linked to CVD, it has remained unclear whether depression or mania underlies the association.

To investigate, the researchers examined the history of mania as an independent risk factor for CVD during an 11.5-year followup of the Baltimore Epidemiologic Catchment Area Followup Study.

A total of 58 patients with a history of mania, 71 with major depressive episodes only, and 1,339 with no mood episodes were psychiatrically assessed in 1981 and 1982.

Incident CVD, comprising myocardial infarction or congestive heart failure, was self-reported in 1993–1996 by 8.77 percent of patients with mania, 7.14 percent of patients with depressive episodes, and 4.27 percent of those with no mood disorders.

The researchers found that after adjusting for age, gender, education, hypertension, smoking, and use of psychotropic drugs, and depressive episodes, patients with mania were 2.97 times more likely to develop CVD than patients with no mood disorders.

Patients with mania were also 2.18 times more likely to develop CVD than patients with major depressive episodes only.

“This study supports previous reports of association between bipolar disorder and CVD and extends the potential relationship to focus on the longitudinal association between mania, hypomania, and incident CVD among community-dwelling persons,” Ramsey and team report in the Journal of Affective Disorders.

They say that the explanation for a greater risk for CVD in patients with mania is likely to be multifactorial.

The team suggests biologic vulnerability as a potential explanation for their finding, noting that patients with mania in their study were, on average, five years younger than those with depressive episodes and nine years younger than those with no mood episodes.

“The physiological impact of labile mood and heightened affective states expedites the aging process, making manic, hypomanic, and bipolar individuals more prone to develop CVD and more vulnerable at a younger age,” they explain.

However, they say other possible reasons might include elevated levels of smoking and substance abuse or dependence in such patients, higher prevalence of cardiovascular risk factors such as diabetes, hypertension, and obesity, and the use of psychotropic medications.

Source: MedWire News

Mania Increases Risk for Cardiovascular Illness

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APA Reference
News Editor, P. (2018). Mania Increases Risk for Cardiovascular Illness. Psych Central. Retrieved on September 25, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 11 Jun 2010)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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