For the first time, scientists have discovered a possible biological culprit in the development of eating disorders during puberty: a type of estrogen called estradiol.
Estradiol is the predominant form of estrogen in females. It is responsible for the growth of reproductive organs and also influences other organs including bones.
Kelly Klump, associate professor of psychology at Michigan State University, and colleagues found that genetic influence on eating disorder symptoms was much greater in pubertal girls with higher levels of estradiol than pubertal girls with lower levels of the hormone. The study appears in the journal Psychological Medicine.
The study examined the estradiol levels of nearly 200 sets of female twins, ages 10-15, from the MSU Twin Registry, which includes more than 5,000 pairs of twins in Michigan.
Klump said previous research had established that eating disorders are influenced by both genetic and environmental factors once a girl hits puberty.
The underlying effects of the genes, however, were unknown.
“The reason we see an increase in genetic influences during puberty is that the genes for disordered eating are essentially getting switched on during that time,” said Klump. “This research was trying to figure out why. What’s turning on the genes during puberty? And what we found is that increases in estradiol apparently are activating genetic risk for eating disorders.”
Klump noted that researchers don’t yet know which genes are being switched on by estradiol. Further, she said a larger study is needed to confirm the results of the MSU-led research.
But knowing that estradiol likely plays a role in the development of eating disorders could ultimately open the window to new treatments, said Klump, past president of the Academy of Eating Disorders.
In addition, she said, prevention efforts could be geared toward those girls who not only are in high-risk environmental contexts (such as weight-focused sports), but also those with genetic risks such as a family history of eating disorders.
Source: Michigan State University