Rejection Can Cause Physical PainNew research suggests the the classic rock and roll song Love Hurts, has validity as scientists discover a breakup in a social relationship can indeed cause physical pain.

The new study shows that small genetic differences in the gene for the opioid receptor can determine the intensity of people’s responses to social rejection.

In the study published in the Proceedings of the National Academy of Sciences, researchers at the University of California in Los Angeles questioned people about their responses to social rejection, which is a form of emotional stress.

They also performed brain scans on people playing a video game in which they were excluded from tossing a ball with computer-generated players.

The results showed that people with a certain mutation in their opioid receptor reacted more strongly to social rejection than those with a normal opioid receptor.

Dr Heilig says that “strengthening the conclusions from this study is the fact that a similar polymorphism [genetic difference] has independently arisen in the rhesus macaque.”

The same portion of the brain that is responsible for the response to physical pain became activated as a result of social rejection, suggesting that, to our brains, emotions really can “hurt.”

Source: Faculty of 1000: Biology and Medicine