advertisement
Home » News » Seizure Meds May Up Risk of Mental Disorders

Seizure Meds May Up Risk of Mental Disorders

Seizure Meds May Up Risk of Mental DisordersProfessionals acknowledge that a history of seizures during infancy increases the risk for development of schizophrenia later in life.

A new study among animal models reveals antiepilectic drug treatments (AED) administered when the brain is developing triggers schizophrenia-like behavior in animals.

The finding brings to question if the seizures, their treatment or perhaps both, increase the risk for schizophrenia in humans.

In research presented at the 39th annual meeting of the Society for Neuroscience, Georgetown University Medical Center researchers show that exposure to AEDs during critical periods of brain development in animal models increases schizophrenia-like behaviors.

“We know that early-life exposure to AEDs such as phenobarbital triggers cell death in many brain regions associated with the onset of schizophrenia,” explains Guillermo Palchik, a doctoral student in the department of pediatrics at GUMC.

“This study not only suggests a relationship between the drugs and schizophrenia, but it raises important questions regarding the side effects of a widely-used class of drugs.

Phenobarbital and other AEDs are not only used as a treatment for seizures but more generally in the treatment of migraines, neuropathic pain and mood disorders, among other ailments, and can be considered drugs of abuse.”

Source: Georgetown University

Seizure Meds May Up Risk of Mental Disorders

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Seizure Meds May Up Risk of Mental Disorders. Psych Central. Retrieved on November 16, 2018, from https://psychcentral.com/news/2009/10/23/seizure-meds-may-up-risk-of-mental-disorders/9123.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.