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Researchers Study OTC Med That May Slow Parkinson’s

A new clinical trial in the U.S. and Canada hopes to determine whether a vitamin-like substance, in high doses, can slow the progression of Parkinson’s disease.

“At present, the very best therapies we have for Parkinson’s can only mask the symptoms — they do not alter the underlying disease,” says Chicago’s Rush University Medical Center neurologist Dr. Katie Kompoliti.

“Finding a treatment that can slow the degenerative course of Parkinson’s is the holy grail of Parkinson’s research.”

The substance being tested, called coenzyme Q10, is produced naturally in the body and is an important link in the chain of chemical reactions that produce energy in mitochondria, the “powerhouses” of cells.

The enzyme is also a potent antioxidant — a chemical that “mops up” potentially harmful chemicals generated during normal metabolism.

Several studies have shown that Parkinson’s patients have impaired mitochondrial function and low levels of coenzyme Q10. Moreover, laboratory research has demonstrated that coenzyme Q10 can protect the area of the brain damaged in Parkinson’s.

The Phase III clinical trial, a large, randomized study with a control group, follows an earlier investigation that tested several doses of coenzyme Q10 in a small group of patients with early-stage Parkinson’s disease. The highest dose, 1200 mg, appeared promising.

Over the course of 16 months, patients taking this dose experienced significantly less decline than other patients in motor (movement) function and ability to carry out activities of daily living, such as feeding or dressing themselves.

But researchers involved in the study, including Kompoliti, were cautious about their findings, citing the need for a more extensive review to confirm the results.

In the present trial, funded by the National Institutes of Health and the National Institute of Neurological and Disorders and Stroke, 600 patients will be enrolled at 60 centers in the U.S. and Canada. Two dosages of coenzyme Q10 are being tested, 1200 mg and 2400 mg, delivered in maple nut-flavored chewable wafers that also contain vitamin E.

Participants in the study will be evaluated periodically over 16 months for symptoms of Parkinson’s disease, including tremor, stiffness of the limbs and trunk, impaired balance and coordination, and slowing of movements. They will also be assessed for ability to perform daily activities, overall quality of life, and need to take medications to alleviate symptoms.

Newly diagnosed patients who are not yet on any medication may be eligible to participate. Rush Uiversity Medical Center is participating in the study. For more information, call (312) 563-2900.

Source: Rush University Medical Center

Researchers Study OTC Med That May Slow Parkinson’s

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Researchers Study OTC Med That May Slow Parkinson’s. Psych Central. Retrieved on June 21, 2018, from https://psychcentral.com/news/2009/09/23/researchers-study-otc-med-that-may-slow-parkinsons/8542.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.