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Understanding How Bipolar Medications Work

New Understanding of Bipolar Medications Although lithium has been the gold standard treatment for bipolar mood disorders for more than 50 years, scientists have never been entirely sure of how it operates in the human brain.

Now, new research from Cardiff University scientists suggests a mechanism for how lithium works, opening the door for potentially more effective treatments.

Laboratory tests on cells have shown that lithium affects a molecule called PIP3 that is important in controlling brain cell signaling. Lithium suppresses the production of inositol, a simple sugar from which PIP3 is made.

Lithium inhibits inositol monophosphatase (IMPase), an enzyme required for making inositol. Importantly, this research shows that increasing the amount of IMPase causes higher levels of PIP3. This can then be reduced by lithium treatment.

High levels of IMPA2, a gene for a variant of IMPase, has previously been linked to bipolar mood disorder. This new result suggests that lithium could counteract the changes in IMPA2.

Professor Adrian Harwood of Cardiff School of Biosciences, who led the research, said: “We still cannot say definitively how lithium can help stabilize bipolar disorder. However, our research does suggest a possible pathway for its operation. By better understanding lithium, we can learn about the genetics of bipolar disorder and develop more potent and selective drugs.

“Further, altered PIP3 signaling is linked to other disorders, including epilepsy and autism, so this well established drug could be used to treat other conditions. Research into lithium could become very important over the next few years.”

Lithium is currently under clinical trial for the treatment of the neurogenerative disorder amyotrophic lateral sclerosis (ALS).

The research, funded by the Wellcome Trust, is published in the journal Disease Models and Mechanisms.

Source: Cardiff University

Understanding How Bipolar Medications Work

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Understanding How Bipolar Medications Work. Psych Central. Retrieved on June 23, 2018, from https://psychcentral.com/news/2009/04/22/understanding-how-bipolar-medications-work/5474.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
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