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New Approach for Alzheimer’s

Alzheimer’s is a progressive and fatal brain disease that affects as many as 5.3 million Americans. As America ages, the incidence of the disorder will rise. Consequently, a new therapeutic approach that targets a protein known as serum amyloid P component (SAP) holds promise.

Professor Mark Pepys studied the protein for over 20 years and has now collaborated with drug manufacturer Roche Pharmaceuticals to develop a new small molecule drug, CPHPC, which specifically targets SAP and removes it from the blood.

In the new work reported in the journal PNAS, the Pepys team together with Professor Martin Rossor and colleagues from the Dementia Research Centre of University College London’s Institute of Neurology, have shown that the drug also removes SAP from the brains of patients with Alzheimer’s disease.

In this first study of the drug in patients with Alzheimer’s disease, CPHPC was given to 5 individuals for 3 months. There was the usual depletion of SAP from the blood, seen in all subjects receiving this treatment, but also remarkable disappearance of SAP from the brain.

Laboratory tests revealed the molecular mechanism responsible for this unique effect and also disclosed for the first time the way in which SAP accumulates in the brain in Alzheimer’s disease.

Administration of CPHPC and the removal of SAP had no side effects in the patients with Alzheimer’s disease. CPHPC has also been given for several years to patients with other diseases without any adverse effects.

“The safety of CPHPC, together with the novel action of the drug in removing SAP from the brain, is very encouraging,” said Professor Rossor.

Although the 3 month treatment period was too short to show any clinical benefit there was no obvious deterioration. Longer and larger scale clinical studies are being planned to confirm safety and seek evidence of benefit to the patients.

“The complete disappearance of SAP from the brain during treatment with CPHPC could not have been confidently predicted” said Professor Pepys, “and the drug, also to our surprise, entered the brain.

“Coupled with the absence of any side effects, these new findings strongly support further clinical studies to see whether longer term treatment with CPHPC protects against the inexorable mental decline in patients with Alzheimer’s disease.”

In December 2008 Roche divested CPHPC entirely to Pentraxin Therapeutics Ltd, a UCL spinoff company founded by Professor Pepys. In February 2009 Pentraxin Therapeutics Ltd licensed CPHPC to GlaxoSmithKline for treatment of systemic amyloidosis, a rare fatal disease. Pentraxin retains the rights to CPHPC for all other indications.

Source: University College London

New Approach for Alzheimer’s

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). New Approach for Alzheimer’s. Psych Central. Retrieved on December 16, 2018, from https://psychcentral.com/news/2009/04/14/new-approach-for-alzheimers/5319.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.