Researchers have developed a test that may help identify frontal lobe dementia (FTD). After Alzheimer’s disease, frontal lobe dementia is the form of dementia that occurs most frequently in patients younger than 65.
In frontal lobe dementia, the disease process starts in the frontal lobe where large numbers of brain cells begin to die off.
The frontal lobe is the foremost part of the brain and constitutes about 30 percent of the brain. Among other things, it is involved in regulating behavior, movement and mood, and it is responsible for cognitive functions such as language.
The first clinical signs of frontal lobe dementia are changes in behavior and personality, and then, in a later stage of the disease, the loss of memory functions.
Progranulin: a main actor
Genetic research has shown previously that there is a genetic defect in chromosome 17 in a large percentage of the families with frontal lobe dementia. There are two genes in chromosome 17 that, if a defect occurs, cause an inheritable form of frontal lobe dementia.
In 1998, defects were found in the gene for the tau protein, a substance that appears in the protein clots in the brains of frontal lobe dementia and Alzheimer’s patients. In 2006, Christine Van Broeckhoven’s team discovered inheritable defects in the gene for the progranulin protein. They predicted that people with these inheritable defects produce only half of the normal amount of progranulin.
This has been confirmed by Christine Van Broeckhoven’s team, who have shown that a shortage of this growth factor leads to the dying off of brain cells in the frontal lobe and in this way causes FTD. New results indicate that progranulin also plays a role in the death of brain cells in other diseases of the brain, such as Alzheimer’s disease and Amyotrophic Lateral Sclerosis (ALS).
On the basis of their research, Kristel Sleegers, a scientist in Van Broeckhoven’s team, has developed a test for measuring the quantity of progranulin in the blood in a simple way. This test enables one to determine whether someone has an increased risk of frontal lobe dementia due to a shortage of progranulin long before symptoms appear.
The blood test can be used on a large scale and is much more simple and user-friendly than the current genetic tests. This finding also offers prospects for the early detection of frontal lobe dementia caused by a shortage of progranulin.
However, it is still too early for a medicine to combat frontal lobe dementia. Further scientific research is needed to determine how a shortage of progranulin can be restored to normal.