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New Genetic Understanding of Schizophrenia

Researchers at the Johns Hopkins University School of Medicine are one gene closer to understanding schizophrenia and related disorders.

Scientists have discovered how a variation in the neuregulin 3 gene influences delusions associated with schizophrenia.

“Neuregulin 3 is clearly one more gene to add to the few currently known to contribute to schizophrenia,” says David Valle, M.D., director of the McKusick-Nathans Institute of Genetic Medicine at Hopkins.

“There’s much more to do, but we’re making progress.”

Schizophrenia is a varied condition with a number of symptoms not shared by all affected. This could be one reason why it’s been difficult to identify genes that contribute to the condition.

To address this, the team first rigorously separated the 73 different symptoms into nine distinct factors associated with the condition — prodromal, negative, delusion, affective, scholastic, adolescent sociability, disorganization, disability, hallucination.

Then, using genetic samples from more than 450 people with schizophrenia and their parents as well as unrelated non-affected people for comparison, the team focused on one region of chromosome 10 that previously had been implicated to contain genes that contribute to the condition.

They analyzed more than 1,400 single nucleotide polymorphisms, or SNPs for short, to see if any particular SNPs were more frequently carried by schizophrenia patients than unaffected people.

They found three SNPs strongly associated with delusions, and all three SNPs are located in the neuregulin 3 gene.

In fact, of the team’s top 20 most significant SNPs, 13 of them are located at or near this gene, but rather than being associated with delusion, the other SNPs are associated with scholastic, disorganization and hallucination factors.

“Neuregulin 3 makes sense because it’s turned on mostly in the central nervous system, and the related gene neuregulin 1 also has been shown to be associated with schizophrenia,” says Dimitrios Avramopoulos, M.D., Ph.D., an associate professor of psychiatry and member of the Institute of Genetic Medicine.

“We’re still at the stage of trying to understand the disease, figuring out what goes wrong in the brain,” says Avramopoulos who adds that the next step for this team is to follow up and sequence the neuregulin 3 gene from a number of the patients in this study to look for rare genetic variants that might also contribute to the condition.

This study was funded by the National Institutes of Health, the National Institute of Mental Health, the Wasie Foundation and the National Alliance for Research on Schizophrenia and Depression.

The report is found in the American Journal of Human Genetics.

Source: Johns Hopkins Medicine

New Genetic Understanding of Schizophrenia

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). New Genetic Understanding of Schizophrenia. Psych Central. Retrieved on June 20, 2018, from https://psychcentral.com/news/2009/02/04/new-genetic-understanding-of-schizophrenia-2/3912.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
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