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Therapeutic Strategy for Alzheimer’s

cellsA new study in the online edition of Nature Medicine describes the function and interaction of a critical molecule involved in cell death in Alzheimer’s disease patients.

These new findings reveal that blocking this molecule, called Cyclophilin D (CypD), and development of surrounding mitochondrial targets may be viable therapeutic strategies for the prevention and treatment of Alzheimer’s disease.

Shi Du Yan, Ph.D. and colleagues believe the new findings strengthen the concept that mitochondrial permeability pores may be central in mitochondrial and neuronal malfunction relevant to Alzheimer disease.

Importantly, these findings may help explain the mechanism of action of a medication already in use in clinical trials.

Mitochondria, the microscopic parts found outside the nucleus of the cell that produce a cell’s energy, are central players in mediating neuronal stress relevant to the pathogenesis or development of neurodegenerative diseases such as Alzheimer’s disease.

Mitochondrial dysfunction, or a problem with the cellular exchange of energy, is an early event observed in Alzheimer’s disease. Recent studies have provided substantial evidence that mitochondria serve as direct targets for amyloid beta (Aβ) protein mediated neuronal toxicity.

The observations that Aβ progressively accumulates in cortical mitochondria from Alzheimer’s disease patients and in brains from transgenic Alzheimer’s disease type mouse models suggest the role of mitochondrial Aβ in the pathogenesis or development of the disease.

This Nature Medicine study describes how this mitochondrial process may be linked to synaptic failure in Alzheimer’s disease.

Source: Columbia University Medical Center

Therapeutic Strategy for Alzheimer’s

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Therapeutic Strategy for Alzheimer’s. Psych Central. Retrieved on October 21, 2018, from https://psychcentral.com/news/2008/11/06/therapeutic-strategy-for-alzheimers/3279.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.