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Epilepsy Drug For Alzheimer’s

drugsA new study suggests a popular epilepsy drug may also be beneficial in patients with Alzheimer’s disease (AD).

The study discusses use of the anti-seizure drug valproic acid to improve memory and reduce brain lesions in mice with an AD-like disease.

Researchers at the University of British Columbia in Vancouver, Canada, showed that treating mice with valproic acid soon after the onset of disease shrank the brain plaques typical of AD and even prompted damaged nerves to start repairing themselves.

Most importantly, the drug improved the animals’ performance in a variety of memory-related tests.

The acid worked by blocking a cascade of enzymatic reactions that culminates in the accumulation of a protein called beta-amyloid, which builds up to toxic levels in AD.

Valproic acid helped mice less as their disease progressed, suggesting that future clinical trials should focus on people with early signs of AD.

Valproic acid has been given to people with AD in the past but memory improvement was never assessed in those studies.

The study was published in the Journal of Experimental Medicine.

Source: Rockefeller University Press

Epilepsy Drug For Alzheimer’s

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Epilepsy Drug For Alzheimer’s. Psych Central. Retrieved on August 18, 2018, from https://psychcentral.com/news/2008/10/28/epilepsy-drug-for-alzheimers/3215.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.