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Vitamin B Does Not Help Alzheimer’s

pillA new clinical trial has shown that high-dose vitamin B supplements do not appear to slow the rate of cognitive decline among individuals with mild to moderate Alzheimer disease.

Scientists from the Alzheimer’s Disease Cooperative Study (ADCS), a multi-center network spanning the United States and Canada, conducted the clinical trial to determine if reduction of an amino acid called homocysteine would reduce the risk of Alzheimer’s disease or slow its progression.

Homocysteine is known to be involved in neurological disease, including Alzheimer’s, and its metabolism is affected by B vitamins. Therefore, it was thought that B vitamin supplements might offer a new therapeutic approach in treating Alzheimer’ disease.

“Prior studies using B vitamin supplementation to reduce homocysteine levels in patients with Alzheimer’s weren’t large enough, or of long enough duration to effectively assess their impact on cognitive decline,” said study authors.

“This study of several hundred individuals over the course of 18 months showed no impact on cognition, although it resulted in lower levels of homocysteine in these patients.”

The study included supplementation with folic acid and vitamins B6 and B12 for 18 months in 409 individuals with mild to moderate Alzheimer’s disease.

Participants were randomly assigned to two groups of unequal size; to increase enrollment, 60 percent were treated with high-dose supplements and the remaining 40 percent treated with identical dosages of placebo. A total of 340 participants (202 in active treatment group and 138 in placebo group) completed the trial while taking study medication.

Cognitive abilities were measured via testing with the Alzheimer Disease Assessment Scale (ADAS-cog).

The researchers found that the ADAS-cog score did not differ significantly between treatment groups, but that symptoms of depression were more common in the high-dose supplement group.

“Our study does not support the treatment of individuals with mild to moderate Alzheimer’s disease and normal vitamin levels with B vitamin supplements,” the authors conclude.

The study will be published in the Journal of the American Medical Association (JAMA).

Source: University of California – San Diego

Vitamin B Does Not Help Alzheimer’s

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Vitamin B Does Not Help Alzheimer’s. Psych Central. Retrieved on June 20, 2018, from https://psychcentral.com/news/2008/10/16/vitamin-b-does-not-help-alzheimers/3146.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.