Vitamin B Does Not Help Alzheimer’s
A new clinical trial has shown that high-dose vitamin B supplements do not appear to slow the rate of cognitive decline among individuals with mild to moderate Alzheimer disease.
Scientists from the Alzheimer’s Disease Cooperative Study (ADCS), a multi-center network spanning the United States and Canada, conducted the clinical trial to determine if reduction of an amino acid called homocysteine would reduce the risk of Alzheimer’s disease or slow its progression.
Homocysteine is known to be involved in neurological disease, including Alzheimer’s, and its metabolism is affected by B vitamins. Therefore, it was thought that B vitamin supplements might offer a new therapeutic approach in treating Alzheimer’ disease.
“Prior studies using B vitamin supplementation to reduce homocysteine levels in patients with Alzheimer’s weren’t large enough, or of long enough duration to effectively assess their impact on cognitive decline,” said study authors.
“This study of several hundred individuals over the course of 18 months showed no impact on cognition, although it resulted in lower levels of homocysteine in these patients.”
The study included supplementation with folic acid and vitamins B6 and B12 for 18 months in 409 individuals with mild to moderate Alzheimer’s disease.
Participants were randomly assigned to two groups of unequal size; to increase enrollment, 60 percent were treated with high-dose supplements and the remaining 40 percent treated with identical dosages of placebo. A total of 340 participants (202 in active treatment group and 138 in placebo group) completed the trial while taking study medication.
Cognitive abilities were measured via testing with the Alzheimer Disease Assessment Scale (ADAS-cog).
The researchers found that the ADAS-cog score did not differ significantly between treatment groups, but that symptoms of depression were more common in the high-dose supplement group.
“Our study does not support the treatment of individuals with mild to moderate Alzheimer’s disease and normal vitamin levels with B vitamin supplements,” the authors conclude.
The study will be published in the Journal of the American Medical Association (JAMA).
Nauert PhD, R. (2015). Vitamin B Does Not Help Alzheimer’s. Psych Central. Retrieved on March 22, 2018, from https://psychcentral.com/news/2008/10/16/vitamin-b-does-not-help-alzheimers/3146.html