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Immature Brain Linked to Schizophrenia

brainAfter extensive study on an animal model, Japanese researchers believe the underdevelopment of a specific region in the brain may lead to schizophrenia in individuals.

According to the research published in the open access journal Molecular Brain, the dentate gyrus, which is located in the hippocampus in the brain and thought to be responsible for working memory and mood regulation, remained immature in an animal model of schizophrenia.

Despite extensive study, the brain mechanisms of schizophrenia remain largely unknown. According to the researchers, one reason for this is that clinical diagnosis in the area of psychiatry is based solely on subjective observations and not on biologically or objectively solid criteria.

“As a result of this limitation, most of the psychiatric disorders currently diagnosed as a single disorder are likely to comprise several biologically distinct heterogeneous populations.

“Therefore, the identification and investigation of more reliable biomarkers that characterize a single subpopulation of a specific psychiatric disorder are essential for increasing the understanding of the pathogenesis/pathophysiology of such disorders.”

The authors note that “‘Immature dentate gyrus’ could provide a basis for such biomarkers that may help produce new diagnosis and treatment for schizophrenia patients”.

Source: National Institute for Physiological Sciences

Immature Brain Linked to Schizophrenia

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Immature Brain Linked to Schizophrenia. Psych Central. Retrieved on December 15, 2018, from https://psychcentral.com/news/2008/09/11/immature-brain-linked-to-schizophrenia/2917.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.