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Drug Combo for Depression

A new research study will investigate if a multiple-medication treatment of depression is superior to the common practice of a single drug. For diseases such as diabetes or hypertension, combining medicines from the start of treatment is common practice.

“We are trying two active, Food and Drug Administration-marketed antidepressant medicines available by prescription from your local drugstore,” said Dr. John Rush, professor of clinical sciences and psychiatry, at UT Southwestern Medical Center.

“There have never been studies prospectively in a large representative sample to see whether the combination of these pills will be better than one.” Rush is CO-MED’s principal investigator and head of the national study.

“The use of combination treatments right at the outset is comparable to similar approaches in a number of other chronic medical illnesses,” said Dr. Madhukar Trivedi, professor of psychiatry and co-principal investigator.

STAR*D, also led by Drs. Rush and Trivedi, was the largest study ever on the treatment of major depressive disorder and is considered a benchmark in the field of depression research. The six-year, $33 million study initially included more than 4,000 patients from sites across the country.

STAR*D provided evidence for step-by-step guidelines to address treatment-resistant depression. Researchers found that only 33 percent of people go into remission in the first 12 weeks of treatment with an antidepressant medication, and of those, about 20 percent relapse. In the course of a year, remission rates for patients who reach the third and fourth treatment steps are even lower.

“While one out of three patients reaching remission is OK, it is not where we need to be,” said Dr. Rush. “That raised the question of how to improve remission rates in the first step in the treatment of depression. How do doctors in the real world fix the problem? They use two drugs.”

The 660 CO-MED study participants will come from the same 15 sites that participated in STAR*D. Participants will be treated randomly with one of two combinations of medications or a single drug.

“If we found a meaningful increase in remission rates with tolerable side affects for people with chronic or recurrent major depression in the first step, results should change practice,” Dr. Rush said.

Dr. Trivedi said, “The major advantage with this approach is not only that we could achieve desired outcomes earlier, but also improve the prognosis in the long term.

“Depression is a serious medical illness that leads to more than 30,000 suicides a year in the U.S. alone,” said Dr. Trivedi.

“Depression also affects the sufferer’s quality of life and costs the economy billions of dollars. If that is the case and we know that subsequent treatment steps do not lead to high symptom remission, should we not change the treatment paradigm so that we utilize logical treatment combinations earlier rather than later?”

Source: UT Southwestern Medical Center

Drug Combo for Depression

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Drug Combo for Depression. Psych Central. Retrieved on February 19, 2019, from
Scientifically Reviewed
Last updated: 8 Aug 2018
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
Published on Psych All rights reserved.