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Some Antidepressants Work Quickly

pillsA single antidepressant tablet makes a depressed person see the world in a more positive light just four hours after swallowing it, suggests a new study.

Dr Philip Cowen, professor of pharmacology at the Department of Psychiatry at the University of Oxford, told delegates at the Royal College of Psychiatrists’ Annual Meeting in London that antidepressant medication starts to work far faster than most clinicians assume.

“Depressed people interpret the world in a negative way,” he said. “They become stuck in this state. Negativity causes depression and depression causes negativity and, whatever happens, events will be interpreted in a negative way.”

Antidepressants elevate mood, which in turn leads to a depressed person becoming more positive and interpreting things that happen to them in a positive way. Prof Cowen said: “Antidepressants change biases. People who take them begin to see the world in a positive light,” said Prof Cowen

But it does not take weeks for this change to happen. Prof Cowen and his colleagues gave 30 depressed people one single 4mg dose of reboxetine – which inhibits the update of both serotonin and noradrenaline in the brain – and compared them with 30 ‘controls’ who were given a placebo or dummy pill.

The researchers asked both groups to carry out a series of simple tasks, including picking out the ‘happy’ facial expression from a line of faces, and recalling positive rather than negative words. They found that the placebo group were poor at spotting happy faces. They also tended to remember the negative words and were slow to categorize positive information.

However, four hours after taking a single dose of reboxetine, the drug group were as capable of remembering the positive words and spotting the happy expression as people who were not depressed.

Prof Cowen said: “People with depression interpret their internal and external worlds in a negative way. The current antidepressant drugs take away the automatic feelings of negativity at the first dose.”

Antidepressants affect mood indirectly by abolishing the negative bias in the way that depressed people appraise personal and social experience at a subconscious level.

While there might be little change in overall conscious mood, Prof Cowen concluded: “Over time, and with a fair wind, this can lead to feeling better and improve the changes of recovery.”

Source: The Royal College of Psychiatrists

Some Antidepressants Work Quickly

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Some Antidepressants Work Quickly. Psych Central. Retrieved on February 17, 2019, from
Scientifically Reviewed
Last updated: 8 Aug 2018
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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