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Anti-Inflammatory for Alzheimer’s

pillsA new study suggests an anti-inflammatory drug may prove effective in reducing the nerve cell damage that hallmarks Alzheimer’s disease.

Brain destruction in Alzheimer’s is caused by the build-up of a protein called amyloid beta in the brain, which triggers damaging inflammation and the destruction of nerve cells.

Scientists had previously shown that preventing individual amyloid beta proteins from sticking to one another minimized brain lesions and protected nerve cells against damage.

The new study—a collaborative effort by researchers in Germany and the US—shows that an anti-inflammatory drug (called CNI-1493) may have the same effect.

The drug—already tested in humans for the treatment of inflammatory diseases—protected nerve cells against amyloid beta –induced damage in culture. In mice prone to developing an Alzheimer’s-like disease, the drug decreased brain inflammation and improved memory and cognitive function.

Other anti-inflammatory drugs, such as ibuprofen, have been shown to reduce Alzheimer’s disease lesions in the brains of rodents, but CNI-1493 appears to be faster and more effective.

If these results hold up in humans, CNI-1493 may provide a more effective alternative to current Alzheimer’s therapies, which temporarily prolong the function of nerve cells but do not prevent their destruction.

Source: Journal of Experimental Medicine

Anti-Inflammatory for Alzheimer’s

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Anti-Inflammatory for Alzheimer’s. Psych Central. Retrieved on October 21, 2018, from https://psychcentral.com/news/2008/06/25/new-anti-inflammatory-for-alzheimers/2498.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.