advertisement
Home » News » Grapes May Aid Alzheimer Treatment

Grapes May Aid Alzheimer Treatment

Researchers have discovered that an extract from grape seeds may help prevent or treat Alzheimer’s disease (AD).

The new Mount Sinai study discovered the beneficial effects of polyphenolics derived from red grape seeds. Researchers believe the findings may lead to the development of ‘wine mimetic pills’ that would replace the recommended beneficial glass of red wine a day for AD prevention.

“Alzheimer’s disease is a neurodegenerative disorder characterized by progressive impairments in memory and cognition,” said Dr. Giulio Maria Pasinetti, senior author and Director of the NCCAM-NIH funded Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer’s Disease at Mount Sinai School of Medicine.

“The study used a naturally derived grape seed polyphenolic extract and demonstrated its efficacy to reduce AD-type Aâ neuropathology as well as cognitive deterioration in the Tg2576 AD mouse model. This natural compound is immediately available to be tested in AD clinical settings to prevent or treat AD.”

Over the past few years researchers at Mount Sinai’s Center of Excellence set out to determine whether the FDA’s recommended daily servings of red wine (approximately one glass for women and two glasses for men), might have the same positive health effect that studies and surveys of populations had shown in the past. They are currently investigating nearly 5000 compounds contained in red wine.

This new study explored the possibility of developing ‘wine mimetic pills’ that would replace the beneficial glass of red wine a day for AD prevention.

Dr. Pasinetti and his collaborators tested the hypothesis that certain molecules contained in red wine, in particular in red grape seeds currently being developed with the name of Meganatural AZ, might offset disease progression in mice genetically modified to develop Alzheimer’ disease.

“Meganatural AZ grape seed extracts significantly reduced Alzheimer’s disease – type cognitive deterioration in the Alzheimer’ disease mice through mechanisms that prevents the formation of a more complex form of a molecule known as amyloid in the brain,” said Dr. Pasinetti.

“The implications of these studies, however, are not limited to patients suffering from Alzheimer’s disease. In fact, amyloid is present in everyone’s brain and whenever it comes together in a more complex structure it makes the brain to function less efficiently like in Alzheimer’ disease. As a result, Meganatural AZ compounds’ ability to inhibit the formation of such ‘more complex’ amyloid structures suggests that Meganatural AZ from red grapes might even help prevent memory loss in people that did not yet developed Alzheimer’s disease.”

Mount Sinai researchers believe they are one step closer to understanding the exact molecule in Meganatural AZ that is responsible for protecting memory and by extension closer to test whether Meganatural AZ can be used in patients affected by Alzheimer’s disease.

Source: The Mount Sinai Hospital / Mount Sinai School of Medicine

Grapes May Aid Alzheimer Treatment

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Grapes May Aid Alzheimer Treatment. Psych Central. Retrieved on August 19, 2018, from https://psychcentral.com/news/2008/06/18/grapes-may-aid-alzheimer-treatment/2473.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.