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Guidelines for Clinical Treatment of Depression

man with doctorAn innovative method to guide clinical treatment of depression is now being tested in a mental and behavioral health care organization. Researchers believe the new protocols will aid primary care physicians assess and treat depression.

UT Southwestern Medical Center psychiatry researchers developed a computerized treatment system based on the results of a six-year study called the Sequenced Treatment Alternatives to Relieve Depression (STAR*D).

The study was the largest ever on the treatment of major depressive disorder and is considered a benchmark in the field of depression research. The six-year, $33 million study initially included more than 4,000 patients from clinics across the country.

STAR*D provided evidence for step-by-step guidelines to address treatment-resistant depression and found that half of depressed patients became symptom-free or had major improvement after the first two treatments with medication.

Based on those findings, Dr. Madhukar Trivedi, professor of psychiatry at UT Southwestern and a leader of the STAR*D study, developed a computerized treatment system and is now testing it in a Nashville, Tenn.-based mental and behavioral health care organization.

“This is exciting because although this project incorporates elements of STAR*D and cutting-edge algorithms developed and refined by UT Southwestern researchers over decades, it moves way beyond that,” said Dr. Trivedi.

The computer software provides a step-by-step guide to assist doctors as they’re treating patients. For example, the program prompts physicians with more specific questions that go beyond “Do you feel better?” after taking medication.

“This computerized system gives doctors assistance at the time that they are seeing the patient,” Dr. Trivedi said. “It’s like walking with someone learning to ride a bike versus just sitting there and telling them how to ride.”
The administration of depression treatment is often inadequate, Dr. Trivedi said.

“Major depressive disorder treatment lags behind the care of other chronic diseases,” said Dr. Trivedi. “It’s not like an infection where you treat for a short time and that’s it.”

Doctors often don’t ask follow-up questions of their patients, and they certainly do not routinely use systematic measurement tools to gauge progress, he said.

“My interest is in helping clinicians, researchers and patients in real-practice settings,” Dr. Trivedi said. “It’s a different magnitude of complexity when you go to a busy clinical practice setting away from academic centers.”

In the STAR*D project, also led by Dr. A. John Rush, professor of clinical sciences and psychiatry at UT Southwestern, only about 50 depression patients from each test-site clinic were selected to participate.

“Studying depression in a very small setting with an isolated patient population was important as we sought to answer certain essential questions, but it is different from the regular practice of doctors and patients,” Dr. Trivedi said.

In the current research project, all patients with depression at study sites will be included. The number of patients could reach 8,000, depending on how many are scheduled for treatment with Centerstone, a nonprofit provider of community-based behavioral health services that has partnered with Dr. Trivedi. Centerstone operates facilities in middle Tennessee and southern Indiana.

“Previous research has pulled out a few drops of water from a pond, whereas now we are looking at the whole pond and all its possible murkiness,” Dr. Trivedi said. Centerstone facilities were chosen in part because of their cohesiveness and technological capabilities.

“We know depression is similar to other chronic illnesses and yet treatable. We know we have a lot of options,” Dr. Trivedi said.

“While we are still developing other treatment alternatives, it’s important to make sure that the research we have now works in the real world. This work with Centerstone will help ensure that depressed patients receive the most effective treatment regime available.”

Source: UT Southwestern Medical Center

Guidelines for Clinical Treatment of Depression

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Guidelines for Clinical Treatment of Depression. Psych Central. Retrieved on February 21, 2019, from
Scientifically Reviewed
Last updated: 8 Aug 2018
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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