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A Hormonal Approach For Depression

pillsNew treatment strategies for major depression could potentially have an immense impact on public health. The novel methods include use of agents that have a broader rate of success or a more rapid onset of action and include use of a natural hormone to mitigate the effects of stress.

The study is published in the journal Biological Psychiatry.

According to the lead author on this study, Kamilla Miskowiak, MSc: “Although depression is often related to problems in the chemistry of the brain, recent evidence also suggests that there may be structural problems as well with nerve cells not being regenerated as fast as normal or suffering from toxic effects of stress and stress hormones.”

This led the researchers to evaluate the effects of erythropoietin (Epo), a hormone naturally produced by the kidneys that stimulates the formation of red blood cells and is known as a treatment for anemia.

The authors explain that new evidence shows that Epo also “has neuroprotective and neurotrophic effects in animal models and affects cognitive and associated neural responses in humans,” suggesting that it may be a candidate in the treatment of depression.

In this study, Miskowiak and colleagues evaluated the effects of Epo on the neural and cognitive processing of emotional information in healthy volunteers using functional magnetic resonance imaging (fMRI).

They found that Epo regulated the emotional responses of those volunteers that received it, similar to the effects of current antidepressants.

Ms. Miskowiak explains that “this finding provides support to the idea that Epo affects neural function and may be a candidate agent for future treatment strategies for depression.”

John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, confirms its potential: “Epo appears to have neurotrophic effects in the brain in animals. The current data suggest that Epo may modulate human brain activity associated with the processing of emotion. Together, there may now be sufficient evidence to justify evaluating the antidepressant effects of Epo and related compounds in humans.”

Source: Elsevier

A Hormonal Approach For Depression

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). A Hormonal Approach For Depression. Psych Central. Retrieved on May 22, 2018, from https://psychcentral.com/news/2007/12/12/a-hormonal-approach-for-depression/1648.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.