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Hormone Fluctuation Tied to Mood Disorders

Woman in WindowA new report provides insights on why women seem to be vulnerable to mood disorders and depression during times of hormonal fluctuations.

In a paper released by the Society for Women’s Health Research, experts acknowledge that although mood disorders and depression may occur at any age during a woman’s life, women seem to more vulnerable during the menstrual period, pregnancy and perimenopause,

During times of hormonal flux, many women are able to emerge relatively unscathed. But for others, a normal hormonal transition can trigger mild to severe mood disorders including depression and bipolar disorder.

“Science has revealed clues as to why these changes may occur in some women,” says Peter Schmidt, M.D., an investigator in the National Institute of Mental Health’s Reproductive Endocrine Studies Unit, “but further research is needed to definitively show what causes depression and mood disorders in women during hormonal transitions.”

The Society for Women’s Health Research and the National Institute for Mental Health convened a thought leaders’ roundtable in June to discuss current efforts to understand the effects of hormonal transitions, specifically pregnancy, postpartum, and perimenopause, on the occurrence of mood disorders in women. The report outlines the participants’ views.

Roundtable participants observed that postpartum depression affects roughly 10 to 15 percent of women up to one year after childbirth, but the exact cause is not known. Some scientists believe that chemical changes in the brain may be caused by the shifts in hormone levels during pregnancy and the post-partum period, leaving women vulnerable to depression. Other life cycle changes in a woman’s life such as perimenopause where hormones are shifting may produce similar emotional disturbances.

Scientific research conducted by Schmidt, David Rubinow, M.D., at the University of North Carolina at Chapel Hill, and their colleagues illustrated the effect of hormones on human mood by shutting down the ovarian cycle in an attempt to eliminate the symptoms of premenstrual syndrome. After two to three months of ovarian suppression, the study participants’ problematic mood symptoms were greatly reduced. The researchers concluded that when reproductive hormones are removed, premenstrual symptoms or PMS disappears.

Despite our present understanding of the effects hormones have on a person’s state of mind, more research is needed. According to the roundtable report, more studies are needed to better distinguish between the normal response to life cycle changes and the symptoms of depression. In addition, more research is needed to figure out why some women are more susceptible to depression during hormonal transitions than others.

In conjunction with the report, the Society for Women’s Health Research revealed the results of a recent national survey polling doctors and their patients. The survey shows that many women underestimate their risk of depression and mood disturbances during hormonal transitions.

“Women need to be critically aware of changes in their moods during key life cycle events,” Sherry Marts, Ph.D. and vice president of scientific affairs for the Society.

“The roundtable began a much needed discussion about the relationship between hormonal transitions and mood disorders. Through the media briefing and the publishing of this report we hope to generate a broader understanding of how we can use this knowledge to improve health outcomes for women.”

Source: Society for Women’s Health Research

Hormone Fluctuation Tied to Mood Disorders

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Hormone Fluctuation Tied to Mood Disorders. Psych Central. Retrieved on February 24, 2019, from
Scientifically Reviewed
Last updated: 8 Aug 2018
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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