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Familial Risk from Parkinson’s

RelativesNew research finds that relatives of patients with Parkinson’s disease may have an increased risk of developing dementia or cognitive impairment.

Parkinson’s disease is characterized by a decline in the functions of the central nervous system, such as motor skills and speech. The new study confirms some earlier studies that found increased risk of dementia in first-degree relatives of Parkinson’s disease patients. However, other studies did not confirm the association.

The report is found in the October issue of Archives of Neurology, one of the JAMA/Archives journals.

“The co-occurrence of Alzheimer’s disease and Parkinson’s disease in families and in individuals may be due to the sharing of susceptibility genetic variants,” the authors write.

Walter A. Rocca, M.D., M.P.H, of the Mayo Clinic College of Medicine, Rochester, Minn., and colleagues studied 1,019 first-degree relatives of 162 patients with Parkinson’s disease, 858 relatives of 147 people who were the same age and sex as someone in the Parkinson’s disease group but did not have the condition and 2,716 relatives of 411 patients with Parkinson’s disease who were referred to the Mayo Clinic.

Dementia and cognitive impairment were determined by responses to a telephone questionnaire or cognitive test and a review of participants’ medical records.

“This study provides evidence that relatives of patients with Parkinson’s disease have an increased risk of cognitive impairment or dementia. This association is primarily driven by families of patients with younger age at onset of Parkinson’s disease, but the risk does not vary across relatives of patients with different clinical characteristics of Parkinson’s disease,” the authors write.

Relatives of patients who experienced the onset of the disease at age 66 or younger had a particularly increased risk of developing dementia or cognitive impairment.

“The observed associations suggest the action of shared familial susceptibility factors, genetic or nongenetic,” they conclude.

Source: JAMA and Archives Journals

Familial Risk from Parkinson’s

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Familial Risk from Parkinson’s. Psych Central. Retrieved on March 25, 2019, from
Scientifically Reviewed
Last updated: 8 Aug 2018
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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