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Smoking Ups Risk for Alzheimer’s

AshtrayIndividuals who smoke are more likely to develop Alzheimer’s disease or dementia than nonsmokers or those who smoked in the past, according to a new study.

Researchers followed nearly 7,000 people age 55 and older for an average of seven years. Over that time, 706 of the participants developed dementia.

People who were current smokers at the time of the study were 50 percent more likely to develop dementia than people who had never smoked or past smokers.

The report is published in the September 4, 2007, issue of Neurology®, the medical journal of the American Academy of Neurology.

Smoking could affect the risk of dementia through several mechanisms, according to study author Monique Breteler, MD, PhD.

“Smoking increases the risk of cerebrovascular disease, which is also tied to dementia,” Breteler said.

“Another mechanism could be through oxidative stress, which can damage cells in the blood vessels and lead to hardening of the arteries. Smokers experience greater oxidative stress than nonsmokers, and increased oxidative stress is also seen in Alzheimer’s disease.”

Oxidative stress occurs when the body has too many free radicals, which are waste products produced by chemical reactions in the body.

“Antioxidants in the diet can eliminate free radicals, and studies have shown that smokers have fewer antioxidants in their diets than nonsmokers,” Breteler said.

The researchers also looked into how smoking affects the risk of developing Alzheimer’s disease for people who have the gene that increases the risk of Alzheimer’s, called apolipoprotein E4, or APOEå4. They found that smoking did not increase the risk of Alzheimer’s for those with the APOEå4 gene.

But for those without the APOEå4 gene, smoking increased the risk of Alzheimer’s. Current smokers without the Alzheimer’s gene were nearly 70 percent more likely to develop Alzheimer’s than nonsmokers or past smokers without the Alzheimer’s gene.

Source: American Academy of Neurology

Smoking Ups Risk for Alzheimer’s

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Smoking Ups Risk for Alzheimer’s. Psych Central. Retrieved on September 21, 2018, from https://psychcentral.com/news/2007/09/05/smoking-ups-risk-for-alzheimers/1230.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.