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Should Antipsychotic Drugs Be Used for Dementia

red pillsMedications used to treat schizophrenia and bipolar disorder have been used for years to treat other conditions, including reducing disruptive behavior among individuals diagnosed with dementia.

The August issue of the Harvard Mental Health letter reviews the use of antipsychotic medications for dementia behaviors, providing information to help friends and families of individuals with dementia.

According to the review, in the last few years, the FDA has required drug labels to carry warnings regarding off-label use, and studies continue to raise questions about its risks and benefits.

Concern about this issue is not new.

A federal law passed in 1987 provides that residents in facilities receiving government support should not receive antipsychotics for problems that are simply inconvenient for caregivers—such as wandering, insomnia, or uncooperativeness—but only for agitated, aggressive, or psychotic behavior that is distressing to the patients or dangerous to others.

But the guidelines have not prevented continued heavy use in institutions for the elderly.

There is some evidence that the drugs can help.

A review of 16 studies found that some antipsychotics might reduce agitation, aggression, and psychosis, although there was little evidence about long-term use.

But for many, the risks outweigh the benefits. The drugs may cause tremors, drowsiness, and weight gain, and they may raise the risk for high cholesterol, diabetes, and heart arrhythmias.

Despite disappointing research findings, clinicians have not given up on the use of antipsychotic drugs for dementia.

Dr. Michael Miller, editor in chief of the Harvard Mental Health Letter notes, “If drug use is necessary, it makes sense to start at a low dose and gradually increase it. The need to continue the drug should be evaluated regularly.”

Clinicians are advised to document their reasons for prescribing the drug and their understanding of the risks and benefits.

Source: Harvard Health Publications

Should Antipsychotic Drugs Be Used for Dementia
APA Reference
Nauert PhD, R. (2018). Should Antipsychotic Drugs Be Used for Dementia. Psych Central. Retrieved on January 16, 2019, from
Scientifically Reviewed
Last updated: 8 Aug 2018
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
Published on Psych All rights reserved.