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Depression Meds May Up Fracture Risk

Experts have long debated whether depression or the medicines used to treat the condition, cause osteoporosis.

The issue is germane as a recent study found that people ages 50 and over who regularly took antidepressants called selective serotonin reuptake inhibitors (SSRIs) had double the rate of fractures as people not using such medications.

However, other research points to depression itself as a source of endocrine changes that can damage bone.
The situation is discussed in the June 2007 issue of Harvard Women’s Health Watch.

Whether the danger comes from depression, the drugs used to treat it, or something else, doctors are paying more attention to this association.

During the 1990s, depression began to emerge as a possible cause of bone loss, rather than a result. Scientists studied women who didn’t have osteoporosis symptoms or even know they had the condition.

They found lower bone mineral density in those who were depressed. Moreover, the link was found in both younger women and women past menopause. Other studies have found a similar relationship, so investigators have been looking at hormones and brain chemicals potentially involved in both depression and bone loss.

Researchers working with an animal model found that depression triggers the release of noradrenaline, which interferes with bone-building cells. Moreover, they found that imipramine—a member of an older class of drugs called tricyclic antidepressants—reversed both depression and depression-induced bone loss.

It may be a long time before the depression-osteoporosis connection is fully clarified.

In the meantime, physicians suggests that you continue taking an antidepressant if you already use one; depression is a serious illness that can have profound consequences. You may also want to talk to your doctor about getting a bone density test, and make sure you get adequate calcium.

Source: Harvard Women’s Health Watch

Depression Meds May Up Fracture Risk
APA Reference
Nauert PhD, R. (2018). Depression Meds May Up Fracture Risk. Psych Central. Retrieved on January 18, 2019, from
Scientifically Reviewed
Last updated: 8 Aug 2018
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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