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Memory Problems Indicate Alzheimer’s

According to a new study, even mild memory problems may be early signs of Alzheimer’s disease. Physicians made the discovery using PET brain scans to measure abnormal protein aggregation growth, or plaque that is associated with Alzheimer’s disease.

For the study, PET scans were performed on the brains of 13 elderly men and women with mild cognitive impairment (MCI) and 14 elderly people without memory problems.

The scans were used to measure uptake of PIB, which is an imaging agent that allows doctors to see and measure abnormal protein aggregation growth, otherwise known as amyloid plaque, in the brain.

Abnormal protein aggregation growth is a signature of Alzheimer’s disease. Until recently, Alzheimer’s disease couldn’t be officially diagnosed until after death with an autopsy.

The study found people with MCI had as much as 39 percent more PIB uptake in some parts of the brain than people without MCI. And about half of the MCI patients had PIB uptake in the Alzheimer’s disease range.

“This pattern of increased PIB in patients with MCI resembles what’s seen in Alzheimer’s disease and is suggestive of an early Alzheimer’s disease process,” said study author Juha O. Rinne, MD, PhD, with the University of Turku in Turku, Finland, and Fellow of the American Academy of Neurology.

“Our findings are similar to what’s seen in post-mortem studies in which abnormal protein aggregation growth is found in people who had been diagnosed with probable Alzheimer’s disease.”

Rinne says larger studies and extended follow-up is needed since identifying people with MCI who have abnormal protein aggregation growth will become increasingly important as treatments affecting such plaque amyloid accumulation become available.

Source: American Academy of Neurology

Memory Problems Indicate Alzheimer’s

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Memory Problems Indicate Alzheimer’s. Psych Central. Retrieved on June 22, 2018, from https://psychcentral.com/news/2007/05/08/memory-problems-indicate-alzheimers/809.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.