Some ACE Inhibitors May Reduce Dementia
New research finds that some high blood pressure medicines may help protect older adults from declines in memory and other cognitive function.
The drugs, found in the class of medicines known as ACE inhibitors, are the compounds that reach the brain and therefore may reduce the inflammation that contributes to Alzheimer’s disease.
Hypertension is a known risk factor for dementia so knowing which medications could mitigate high blood pressure while reducing later cognitive risks is important.
The report by researchers from Wake Forest University School of Medicine, was reported at the annual meeting of the American Geriatrics Society in Seattle.
“For older adults who are going to take an ACE inhibitor drug for blood pressure control, it makes sense for their doctors to prescribe one that goes into the brain,” said lead researcher Kaycee Sink, M.D., M.A.S..
Some ACE (angiotensin-converting enzyme) inhibitors are known as centrally acting because they can cross the blood brain barrier, a specialized system of tiny blood vessels that protects the brain from harmful substances in the blood stream.
Centrally acting drugs include captropril (Capoten®), fosinopril (Monopril®), lisinopril (Prinivil® or Zestri®), perindopril (Aceon®), ramipril (Altace®) and trandolapril (Mavik®).
The study found a link between taking centrally active ACE inhibitors and lower rates of mental decline as measured by the Modified Mini-Mental State Exam, a test that evaluates memory, language, abstract reasoning and other cognitive functions.
For each year that participants were exposed to ACE inhibitors that cross the blood brain barrier, the decline in test results was 50 percent lower than the decline in people taking other kinds of high blood pressure pills.
The researchers also found that non-centrally active ACE inhibitors were associated with a trend towards an increased risk of dementia. However, the results were not statistically significant, which means that they could have occurred by chance.
Dementia was diagnosed by a panel of physicians after reviewing results of magnetic resonance imaging and other tests.
“These results suggest that there is more to treating blood pressure than achieving a goal of 140/80,” said Sink.
“Which drug you choose for blood pressure control can have broader implications. We know that ACE inhibitors protect against heart failure and kidney failure, and now there is evidence that some of them may also protect against dementia.”
Sink said the effects may be related to reducing inflammation in the brain.
“The hypothesis for how they may slow cognitive decline is that they are decreasing inflammation in the brain, and we know that inflammation is important in the development of Alzheimer’s disease,” she said.
Compared to other anti-hypertensive drugs, there was no association between exposure to ACE inhibitors as a class and the risk of dementia. The benefits clearly came from taking the centrally active drugs.
“We need to confirm the results in a study in which people are randomly selected to receive either ACE inhibitors that are centrally active or those that aren’t,” said Sink.
“Hypertension is a risk factor for dementia, so it’s important to know if the type of drug pressure medication a person takes can cut that risk.”
Nauert PhD, R. (2015). Some ACE Inhibitors May Reduce Dementia. Psych Central. Retrieved on March 22, 2018, from https://psychcentral.com/news/2007/05/07/some-ace-inhibitors-may-reduce-dementia/806.html