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HRT Before Age 65 Reduces Alzheimer’s Risk

New research suggests women who begin to use the hormone estrogen before age 65 may decrease their risk for developing dementia or Alzheimer’s.
Researchers discovered women who used any form of estrogen hormone therapy before the age of 65 were nearly 50 percent less likely to develop Alzheimer’s disease or dementia than women who did not use hormone therapy before age 65.

The study was part of the Women’s Health Initiative Memory Study, which is a sub-study of the Women’s Health Initiative (WHI), one of the largest U.S. prevention studies of postmenopausal women.

The study looked at prior hormone use in 7,153 healthy women ages 65-79 before they enrolled in the WHI Memory Study. Researchers followed the women’s cognitive health over an average of five years.

In that time, 106 of the women developed Alzheimer’s disease or dementia. Dementia is a general term referring to the progressive decline in a person’s cognitive function. Dementia can affect memory, attention, language and problem solving abilities. Alzheimer’s is the most common type of dementia.

Prior studies have shown that hormone therapy started during the WHI Memory Study increased a woman’s chance of dementia. The reduced risk of dementia was seen only with prior hormone therapy, used before study enrollment. Reduced risk was not affected by other examined factors.

Women who began estrogen-only therapy after the age of 65 had roughly a 50-percent increased risk of developing dementia. The risk jumped to nearly double for women using estrogen-plus-progestin hormone therapy.

“Further studies are needed to support these findings and learn more about how hormone therapy affects the long-term cognitive health of women who begin use before age 65,” said Henderson.

Source: American Academy of Neurology

HRT Before Age 65 Reduces Alzheimer’s Risk

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). HRT Before Age 65 Reduces Alzheimer’s Risk. Psych Central. Retrieved on May 24, 2018, from https://psychcentral.com/news/2007/05/04/hrt-before-age-65-reduces-alzheimers-risk/803.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.