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Omega-3s Lower Risk of Depression

According to a new study, an individual’s diet may not only lead them to be at risk of developing certain inflammatory diseases but may also place them at risk for clinical depression. Researchers say a diet should contain a better balance of omega-6 and omega-3 polyunsaturated fatty acids.

The current typical American diet contains 20 times more omega-6 than omega-3, a ratio that researchers say should be lowered to 4-to-1, or even 2-to-1.

Ohio State University researchers publish this finding, the latest in a series of investigation on the links between diet, psychological stress and immunity in the journal Psychosomatic Medicine.

The current study adds dietary questions to earlier work that focused solely on emotional and biochemical markers impact on the immune system.

“In this study, we’re looking at the intersection of behavior, immune function and diet. In past experiments, we concentrated only on the first two,” explained Jan Kiecolt-Glaser, professor of psychiatry and psychology at Ohio State and lead author on the paper.

“It now appears that diet is a very important variable in the equation as to how people respond to depression and stress.”

The study, conducted in OSU’s Institute for Behavioral Medicine Research, focused on a group of 43 middle-aged to elderly men and women, nearly half of which were the caregiver spouses of people with Alzheimer’s or other dementias. By including caregivers who typically report greater stress and more depression than similar adults who are not caregiving, the researchers could look at how depression and diet might interact to affect inflammation.

Blood samples were drawn from each person in the study and tested for interleukin-6 (IL-6), tumor necrosis factor -alpha (TNF-alpha ) and the receptor molecule for IL-6. Participants also completed a survey questionnaire that gauged their level of depression.

The analysis showed that participants who had much more omega-6 — compared to omega-3 — fatty acids, and who also were reporting more symptoms of depression, had much higher levels of IL-6 and TNF-alpha, two cytokines which enhance inflammation.

“The data suggest that higher depression and a poorer diet in terms of omega-3 can work together to promote inflammation. Other researchers have shown that clinically depressed people — those with more severe depression — often have lower omega-3 levels in their blood, and several studies have shown that supplementing diets with omega-3 improves depression,” Kiecolt-Glaser said, although the reason isn’t clear.

“People who are depressed don’t eat well, or it might be that there is something about depression that affects how well people process such foods.”

In recent years, research has shown that an increase in omega-3 fatty acids in the diet has specific health benefits, especially in patients with depression, cardiovascular disease and inflammatory and autoimmune diseases.

Martha Belury, an associate professor of human nutrition, endocrinology, diabetes & metabolism at Ohio State and co-author of the study, said the design of the study was important.

“We looked at people who were experiencing real depression, not those whose depression arose as a part of some experiment, and we could clearly see a relationship between lower omega-3 fatty acids and certain markers of depression and inflammation.”

Belury said that current recommendations allow up to two servings each week of cold-water fish – the best source of omega-3 – such as salmon or trout. This would not apply to pregnant women, she said, where concerns are greater about the heavy metal contamination such fish might contain. Omega-3 is also available as nutritional supplements.

“This study has shown that even in people who did not take supplements, maybe just a little bit more omega-3, could help reduce their markers for both stress and depression,” Belury said.

“The important message for consumers is that they don’t have to take mega-doses of omega-3 to have some impact. It might not take a whole lot to have a significant clinical impact,” Belury said.

The researchers are now starting a larger, more comprehensive randomized and controlled trial of omega-3 in adults between the ages of 50 and 80 in hopes of testing the questions raised in this pilot study.

Source: Ohio State University

Omega-3s Lower Risk of Depression

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Omega-3s Lower Risk of Depression. Psych Central. Retrieved on March 25, 2019, from
Scientifically Reviewed
Last updated: 8 Aug 2018
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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