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Use Caution with Lithium Drugs

Laboratory findings suggest that lithium and other drugs that inhibit a particular enzyme, GSK-3 beta, should be used with caution in treating Alzheimer’s disease because too high a dose can impair, rather than enhance, nerve function.Lithium is currently in clinical trials for treating Alzheimer’s.

Pharmaceutical companies are interested in producing other GSK-3 beta inhibitors for the disease because these drugs are relatively easy to make and lithium has been shown to be safe in low doses in treating people with manic-depressive illness, said Dr. William D. Snider, professor of neurology, cell and molecular physiology at the University of North Carolina at Chapel Hill’s School of Medicine.

“People might think that if you make the inhibitor stronger and stronger, that would be better. Our in-vitro experiments show that you will have to be careful with how you use GSK-3 beta inhibitors, because if you use too much, it will interfere with and possibly kill neurons,” said Snider, who also is director of UNC’s Neuroscience Center.

The results, published online Thursday (Dec. 21) in the journal Neuron, were surprising because GSK-3 beta inhibitors have been shown at some doses to improve neuronal function. “It’s known that when GSK-3 beta is inactivated that tends to allow the processes inside the cell it regulates to function normally,” Snider said.

But when the researchers strongly inhibited GSK-3 beta in mouse neurons in cell culture, the growth of axons, which carry messages between nerve cells, was markedly reduced.

The researchers inhibited GSK-3 beta using RNA silencing. “RNA silencing allows you to specifically knock down the level of a particular protein inside the cell,” Snider said.

In a second set of experiments, the researchers treated mouse neurons with a low dose and a high dose of a GSK-3 beta inhibitor similar to lithium. The high dose impaired neuronal function, while the low dose improved it.

The study was funded by the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health.
Snider’s group plans to further investigate the effect of inhibiting GSK-3 beta in a whole-mouse model. “We will take a conditional mutagenesis approach in mice to knock out the GSK-3 beta in the nervous system,” Snider said. “We’ll be able to find out if we get the same effect in the whole animal that we got using RNA silencing in the culture dish.”

The researchers will also work to understand how GSK-3 operates in relation to a protein called Tau, which is implicated in Alzheimer’s.

Source: University of North Carolina at Chapel Hill School of Medicine

Use Caution with Lithium Drugs

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Use Caution with Lithium Drugs. Psych Central. Retrieved on September 19, 2018, from https://psychcentral.com/news/2006/12/22/use-caution-with-lithium-drugs/496.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.