Researchers have discovered a group of cells in the brain believed to be responsible for an alcoholic’s craving for alcohol. The cells, located in the part of the brain called the hypothalamus, are a system of neuropeptide hormones termed Orexin. Orexins were originally associated with the regulation of food intake but additional study found Orexin is also involved in the ‘high’ felt after drinking alcohol or taking illicit drugs.
Australian scientists discovered the system can not only stop an alcoholic’s craving for alcohol, abut can also prevent relapse once they have recovered from alcohol addiction.
In studies conducted with rats, Dr Andrew Lawrence and his colleagues at Melbourne’s Howard Florey Institute used a drug that blocked Orexin’s euphoric effects in the brain and the results were remarkable.
“In one experiment, rats that had alcohol freely available to them stopped drinking it after receiving the Orexin blocker.” Dr Lawrence said.
“In another experiment, rats that had gone through a detox program and were then given the Orexin blocking drug, did not relapse into alcohol addiction when they were reintroduced to an environment in which they had been conditioned to associate with alcohol use.
“Orexin reinforces the euphoria felt when drinking alcohol, so if a drug can be developed to block the Orexin system in humans, we should be able to stop an alcoholic’s craving for alcohol, as well as preventing relapse once the alcoholic has recovered,” he said.
Dr Lawrence said that this research could also lead to treatments for eating disorders, such chronic over-eating, which leads to obesity.
“Our research shows that alcohol addiction and eating disorders set off common triggers in the brain, so further investigations may uncover drug targets in the Orexin system to treat both conditions,” Dr Lawrence said.
The Florey scientists are now conducting multiple experiments to discover the precise circumstances that activate the Orexin system.
“To explore this discovery further we are now investigating how different experimental paradigms and environmental situations impact on the Orexin system, which will hopefully pinpoint therapeutic drug targets,” Dr Lawrence said.
“Before a therapeutic Orexin-blocking drug can be developed, we need to ensure that it will be safe to use in the long-term and that issues surrounding a person’s compliance in taking the drug are considered,” he said.
According to the World Health Organization, alcohol is one of the most widely used and abused substances in the world and causes as much, if not more death and disability as measles, malaria, tobacco, or illegal drugs.
Source: Research Australia