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Teen Depression and Medication Efficacy

A recent study adds insight on the controversial use of antidepressant drugs for teenage depression. Researchers have discovered that the short duration of depressive symptoms in this age group makes it difficult to distinguish drug efficacy from placebo. The finding is salient as some believe the medications are linked to an increased risk for suicide in this age cohort.

Further, at an FDA meeting reviewing this topic, the majority of clinical trials examined did not show that the drugs were effective in treating depression in children and adolescents.

Researchers from the Department of Psychiatry at Drexel University College of Medicine and Philadelphia Health & Education Corporation published their findings in the September issue of the Journal of Clinical Pharmacology.

Using a naturalistic study design, the researchers advise using multiple assessments to establish a continuous baseline before randomizing patients to treatment, which would remove those who spontaneously recover in a very short period of time.

In addition to having an impact on the accuracy of future clinical trials, this approach may help decrease the number of children who are exposed to unnecessary long-term drug therapy and possible side effects, since those who spontaneously recover quickly would not be started on drug therapy.

The article “Impersistence of Depression in Youth: Implications for Drug Study Design” can be accessed at no-charge for a limited time at The Journal of Clinical Pharmacology’s web site at www.jclinpharm.org/cgi/reprint/46/9/1044.

Source: SAGE Publications

Teen Depression and Medication Efficacy

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Teen Depression and Medication Efficacy. Psych Central. Retrieved on May 26, 2018, from https://psychcentral.com/news/2006/09/13/challenge-to-evaluate-teen-depression-and-drug-efficacy/263.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.