A new study warns that marijuana use at the time of conception and early in pregnancy may cause the pregnancy to fail. Researchers believe tetrahydrocannabinol (THC), the major psychoactive component of marijuana, causes impaired fertility by disturbing the natural balance of a molecule responsible for normal embryonic development.

In a study of mice, scientists from Vanderbilt University found THC and drugs that act in a similar fashion prevent the embryos’ safe passage from the ovary to the uterus. If a similar action is found in humans, an ectopic pregnancy and/or impaired fertility in women may result.

The study appears in the August issue of the Journal of Clinical Investigation.

Marijuana, the most widely used illegal drug among women of reproductive age, binds to 2 receptors – cannabinoid receptors 1 and 2 (CB1, CB2) – which are found in the brain and other organs including sperm, eggs, and newly formed embryos. Normally, these 2 receptors are activated by the naturally occurring signaling molecule anandamide. Anandamide formation by the enzyme NAPE-PLD is carefully balanced with its degradation by the enzyme FAAH, resulting in a finely tuned local “anandamide tone” in embryos and the oviduct. This balance is required for normal embryonic development, transport along the oviduct, implantation in the uterus, and full-term pregnancy.

In the current study, Sudhansu Dey and colleagues from Vanderbilt University show that suppression of FAAH activity in the embryos and oviduct elevates anandamide levels, which inhibits embryonic development and prevents embryos from completing their passage to the uterus, causing impaired fertility.

They went on to show that administration to the mice of tetrahydrocannabinol (THC), the major psychoactive component of marijuana that like anandamide also binds to CB1, swamps normal anandamide tone, causing implantation of the embryo in the earliest stages of pregnancy to fail. The results of the study show that drugs such as THC persist and swamp these finely tuned signaling systems and as such the use of THC-containing drugs such as marijuana may lead to ectopic pregnancy and/or impaired fertility in women.

Source: Journal of Clinical Investigation