advertisement
Home » News » Cell Stress May Cause Brain Disease

Cell Stress May Cause Brain Disease

Brain disorders such as Parkinson’s, Alzheimer’s, Amyotropic lateral sclerosis (Lou Gehrig’s disease) and other neurodegenerative brain ailments result from oxidative stress during metabolism.

Researchers working on a mammalian brain have discovered a biomarker that may aid early identification of the disorders before symptoms occur. Scientist believe the early detection of the as-yet incurable diseases may be key in reversing the cellular malfunction.

The findings, a result of research by the Department of Energy’s Pacific Northwest National Laboratory and UCLA’s David Geffen School of Medicine, revealed that cellular damage is linked to a natural byproduct of oxidation called nitration.

“We looked at a healthy brain and found nitration of proteins that are implicated in neurodegenerative disease,” said Colette Sacksteder, PNNL scientist and lead author of the study, published in the July issue of the journal Biochemistry (online Wed., June 28). PNNL scientist Wei-Jun Qian was co-lead author.

The results are from the most detailed proteomic analysis of a mammalian brain to date – that is, a survey of nearly 8,000 different, detectable proteins in the mouse brain. The research suggests that many neurodegenerative diseases leave a biochemical calling card, or biomarker, that could be used to predict the earliest stages of brain impairment.

The biomarker is known as nitrotyrosine, made when an amino acid in the brain, tyrosine, is in the presence of an oxidative-stress molecule called peroxynitrate. The biomarker was found on 31 sites along 29 different proteins, half of which had been previously implicated in several of the neurodegenerative diseases.

“Our study certainly suggests that the sensitivity of certain proteins to peroxynitrite is an early contributor to neurodegeneration, but other factors may also be involved,” said Diana Bigelow, PNNL staff scientist and the paper’s corresponding author. “The next step, of explicitly looking at tissues with neurodegenerative disease, will test this hypothesis.”

Source: DOE/Pacific Northwest National Laboratory

Cell Stress May Cause Brain Disease

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2016). Cell Stress May Cause Brain Disease. Psych Central. Retrieved on December 10, 2018, from https://psychcentral.com/news/2006/06/28/cell-stress-may-cause-brain-disease/49.html

 

Scientifically Reviewed
Last updated: 27 Jun 2016
Last reviewed: By John M. Grohol, Psy.D. on 27 Jun 2016
Published on PsychCentral.com. All rights reserved.