Home » News » Is Early Memory Loss Alzheimer’s?

Is Early Memory Loss Alzheimer’s?

An occasional memory loss has long been thought to be a ‘normal’ characteristic of the aging process. The event is so common many refer to the event as a ‘senior moment’. New research suggests the episodic loss of memory may represent the beginning of Alzheimer’s disease.

The study, published in the June 27, 2006, issue of Neurology, evaluated 134 older men and women who didn’t have cognitive impairment at the time of their death.

Participants came from the Religious Orders Study and the Memory and Aging Project. Both are longitudinal, clinical-pathologic studies of older persons without dementia who underwent annual clinical evaluations and several cognitive performance tests. After they died, their brains were examined at autopsy for evidence of pathology.

More than a third of the participants (50) met criteria for a pathologic diagnosis of Alzheimer’s disease. Criteria included lesions of brain tissue on the autopsy. This group also scored significantly lower than the other participants on tests for episodic memory, such as recalling stories and word lists.

“The results provide evidence in support of the idea that some type of neural reserve can allow a large number of older persons to tolerate a significant amount of Alzheimer’s pathology without manifesting obvious dementia,” said study author David A. Bennett, MD, of the Rush Alzheimer’s Disease Center in Chicago.

Scores on the Mini Mental State Examination, a mental status screening test of cognitive functions, were nearly identical for participants with and without a pathologic diagnosis of Alzheimer’s disease.

“This study questions the acceptability of minor episodic memory loss in older adults as ‘normal’,” said Carol F. Lippa, MD, who wrote an editorial in the same issue of Neurology. “Maybe this early decline in episodic memory precedes mild cognitive impairment and should be the target of research efforts in the early detection of Alzheimer’s disease.”

The study was supported by grants from the National Institute on Aging.

Source: American Academy of Neurology

Is Early Memory Loss Alzheimer’s?

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Is Early Memory Loss Alzheimer’s?. Psych Central. Retrieved on January 24, 2019, from
Scientifically Reviewed
Last updated: 8 Aug 2018
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
Published on Psych All rights reserved.