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Choosing the Best SSRI

Comparison of SSRIs’ Use, Efficacy and Side Effects

The condition or conditions for which a medication is prescribed is termed its indications or use. How well it does what it is supposed to do is termed efficacy; and how well it avoids causing other symptoms is determined by the number and severity of its side effects. Because each of the SSRIs has a unique molecular structure, it is possible to compare them with one another for these characteristics.

In terms of use, all SSRIs except Luvox (fluvoxamine) are FDA-approved for treatment of depression. Luvox is approved in the U.S. only for treating obsessive-compulsive disorders, although it is used internationally for depression, too.

As Preskorn pointed out, rigorous studies of the SSRIs to one another would be ideal and useful in comparing efficacy and side effects, but no such study exists or is likely to be undertaken. However, that doesn’t mean these drugs’ outcomes can’t be compared.

In his opinion, there’s a lot that can be determined based on the large number of SSRI studies that have been done. For example, he noted, the following features have generally been reported as similar across the class:

  • Flat-dose antidepressant-response curves — or the ability to produce the same average response rate at each dose above the effective, minimum dose over the dosing range;
  • Equivalent antidepressant action at their usually effective therapeutic dose (however, data for fluvoxamine was not available for comparison);
  • Similar efficacy when used on a maintenance basis to prevent relapse;
  • The usually effective minimum dose of each produces 60 percent to 80 percent inhibition of serotonin uptake;
  • All have benign adverse side effects when compared to drugs in the tricyclic class.

All Work Equally Well for Many

Michael Messer, medical director of ThedaCare Behavioral Health in Appleton, Wis., said that the marked similarity of the five SSRIs means that all are generally appropriate for a wide range of individuals. “For a physically healthy person between 20 to 50 years of age not taking any other medications, any of the SSRIs will probably work equally well, with a comparable number and type of side effects, generally dependent on the dose,” he explained.

Messer noted side effects, when they do occur, are also similar and range in severity from mild to severe. They include interruptions in sexual performance, headaches, anorexia, diarrhea, nervousness, tremors and insomnia. According to Messer, the SSRIs’ effect on sexual performance is often the most pronounced undesirable outcome. “In patients who experience this side effect, interest in sex, as well as orgasmic response can be affected,” he said. “However, since recovery of sexual performance occurs after SSRIs are discontinued, many patients will tolerate these effects to gain the medications’ overall beneficial impact.”

Differences in Efficacy, Side Effects Do Exist

Both Messer and Preskorn pointed out that for older individuals, patients with medical conditions in addition to the one for which the SSRI is prescribed, or those taking other medications at the same time, some SSRIs may be less appropriate than others. This has to do with their pharmacokinetic characteristics, which Preskorn describes as “clinically different” from one another.

These differences include how each of them bind proteins; which of several specific enzymes in the body each one depends upon for chemical transformation; how long each persists in the body; and which metabolites or chemical byproducts each one produces.

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Physician-Patient Collaboration Key

The experts agreed there’s no single SSRI that’s universally best for all patients. The choice of the best SSRI for individuals older than 50, or those who have other medical conditions or medication needs is one that requires careful consideration of both the characteristics of the patient as well as the distinct chemical features of each specific drug.

Choosing the Best SSRI

Jane Framingham, Ph.D.

APA Reference
Framingham, J. (2020). Choosing the Best SSRI. Psych Central. Retrieved on August 13, 2020, from
Scientifically Reviewed
Last updated: 14 Jan 2020 (Originally: 17 May 2016)
Last reviewed: By a member of our scientific advisory board on 14 Jan 2020
Published on Psych All rights reserved.