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Generic Name: Tranylcypromine (TRAN-il-SIP-roe-meen)

Drug Class: Monoamine Oxidase Inhibitors

Table of Contents

Parnate (Tranylcypromine)Parnate (Tranylcypromine)






Parnate (Tranylcypromine) is a monoamine oxidase inhibitor (MAOI) that works by increasing the levels of certain chemicals in the brain to treat major depressive episodes in adults who have not been helped with other medications. Tranylcypromine will not treat bipolar disorder (manic depression).

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.

It works by helping change certain chemicals in the brain, which professionals refer to as “neurotransmitters.” It is not yet well-understood why changing these neurochemicals results in symptom relief for the conditions this drug is commonly prescribed for.

How to Take It

Follow the directions for using this medicine provided by your doctor. This medicine may be taken on an empty stomach or with food. Continue to take this medicine even if you feel well. Do not miss any doses.

Side Effects

Side effects that may occur while taking this medicine include:

  • abdominal pain
  • dry mouth
  • weakness
  • muscle spasm
  • itching
  • drowsiness
  • blurred vision
  • sleep problems such as insomnia

Contact your doctor immediately if you experience:

  • lethargy
  • depression
  • confusion
  • bruising or bleeding easily
  • seizure
  • vomiting
  • anxiety
  • pinpoint red spots on the skin
  • swollen glands

Warnings & Precautions

  • If you plan to have surgery, a CT scan, x-ray, or MRI of your spinal cord, you may need to stop using this medicine for a brief period of time. Tell the doctor treating you that you are taking tranylcypromine.
  • DO NOT eat foods that have high levels of tyramine or drink alcohol while taking this medication.
  • Use caution if you drive or operate machinery while taking Tranylcypromine. It can impair your thinking and reactions.
  • Stop taking this medication and call your doctor immediately if you experience any of the following symptoms: uncontrollable muscle twitches, sensitivity to light, lack of coordination, frequent headaches, ankle swelling, confusion, tight feeling in the chest, or rapid heartbeat.
  •  DO NOT take more of this medication than is prescribed. It may be habit-forming. Call your doctor if you find that you want to take extra medication or you notice any other unusual changes in your behavior or mood.
  • Do not give this medicine to a child younger than 18 years old without medical advice.
  • For an overdose, seek medical attention immediately. For non-emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

Before taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. This includes supplements and herbal products.

Dosage & Missed Dose

Follow instructions as prescribed by your doctor. Do not take Parnate in larger or smaller amounts or for longer than recommended.

Your dosage may be changed by your doctor occasionally in order to maximize effectiveness.

If you skip a dose, take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses or take extra medicine to make up for the missed dose.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (preferably not in the bathroom). Throw away any medication that is outdated or no longer needed.


If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using this medicine during pregnancy.  Tranylcypromine can pass into breast milk and may harm a nursing baby. It is recommended that you do not breastfeed while nursing a baby.

More Information

For more information, talk to your doctor, pharmacist or health care provider, or you can visit this website, for additional information from the manufacturer of this drug.



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APA Reference
Psych Central. (2018). Parnate. Psych Central. Retrieved on September 27, 2020, from


Scientifically Reviewed
Last updated: 8 Oct 2018
Last reviewed: By Christine Traxler, M.D.
Published on All rights reserved.