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Generic Name: Thiothixene (thy-oh-THIX-een)

Drug Class: Antipsychotic

Table of Contents

Thiothixene Navane






Navane (Thiothixene) is is classified as an antipsychotic medication and is used to treat schizophrenic patients that suffer from delusions, hallucinations, unorganized thoughts, and hostility. Thiothixene may be prescribed by your doctor for other uses as well.

Thiothixene is not approved for use in psychotic conditions related to dementia. For older adults with dementia-related conditions, it may increase the risk of death.

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.

It works by helping change certain chemicals in the brain, which professionals refer to as “neurotransmitters.” It is not yet well-understood why changing these neurochemicals results in symptom relief for the conditions this drug is commonly prescribed for.

How to Take It

Take this medicine exactly as directed by your doctor or pharmacist. This medicine should be taken continually, even if you are feeling better. Thiothixene comes as a capsule and a liquid concentrate to be taken by orally. This medicine is generally given two to three times a day. Follow the directions on your prescription label. Do not take more or less of this medicine than prescribed. Do not share this medicine with other people.

Side Effects

Side effects that may occur while taking this medicine include:

  • severe sunburn
  • dry mouth or extreme thirst
  • sleeplessness or drowsiness
  • stuffy nose
  • constipation
  • blood pressure drop upon standing
  • skin discoloration
  • restlessness

Contact your doctor immediately if you experience:

  • wheezing
  • confusion
  • depression
  • difficulty breathing
  • unusual bleeding or bruising
  • eye pain or discoloration
  • cough
  • fast or irregular heartbeat
  • shuffling walk
  • increased sweating
  • slow or jerky movements
  • chest tightness
  • rash
  • problems urinating
  • movements of the face or jaw
  • hyperventilation
  • loss of consciousness
  • extreme tiredness

Warnings & Precautions

  • Let your doctor know if you are allergic to thiothixene or any other medications.
  • Tell your doctor or dentist that you are taking this medicine if you are having surgery.
  • DO NOT use this medicine if you have blood disorders, epilepsy/seizure disorders, severe circulation problems, low white blood cell (WBC) counts, bone marrow issues, or if you had/have breast cancer.
  • This medicine can cause dizziness or drowsiness.
  • Alcoholic beverages can increase the effects of this medicine and should be avoided.
  • DO NOT use this medicine if you are also taking Tramadol.
  • DO NOT use this medicine if you have drowsiness, slow breathing, weak pulse, or decreased alertness
  • Avoid long exposure to the sun. Wear protective clothing and use sunscreen. Thiothixene can increase your skin’s sensitivity to sunlight, making it easier for you to burn. Also avoid sunlamps.
  • For an overdose, seek medical attention immediately. For non-emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

Before taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. This includes supplements and herbal products.

Let your doctor know if you are taking Metoclopramide/Antipsychotics, Phenothiazines, Rivastigmine, Sibutramine/Antipsychotics, Selected dopamine agonists/, selected antipsychotics, Lithium/selected phenothiazines or Cabergoline/selected dopamine Blockers.

Dosage & Missed Dose

Follow all directions on your prescription label as prescribed by your doctor. Your dosage may be changed occasionally for best results.

If your symptoms do not improve during treatment, consult with your doctor. Regular medical tests are required while you are taking this medication to ensure it is not causing harmful effects. Visit your doctor regularly.

Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses or take extra medicine to make up for the missed dose.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (preferably not in the bathroom). Throw away any medication that is outdated or no longer needed.


Tell your doctor if you are pregnant or planning to become pregnant. Since thiothixene is excreted in human breast milk, you should NOT breastfeed while taking this medicine.

More Information

For more information, talk to your doctor, pharmacist, or health care provider, or you can visit this website, for additional information from the manufacturer of this drug.



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APA Reference
Psych Central. (2018). Navane. Psych Central. Retrieved on October 26, 2020, from


Scientifically Reviewed
Last updated: 8 Oct 2018
Last reviewed: By Christine Traxler, M.D.
Published on All rights reserved.