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Generic Name: Loxapine (LOX-a-peen)

Drug Class: Dibenzoxazepine, Tricyclic Antipsychotic

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Loxitane (Loxapine) is an antipsychotic medication used to treat schizophrenia. It can reduce the desire to hurt yourself or others, encourage clear thinking and make you feel less nervous and less aggressive.

Loxapine is not approved for use in dementia-related psychotic conditions.

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.

It works by helping change certain chemicals in the brain, which professionals refer to as “neurotransmitters.” It is not yet well-understood why changing these neurochemicals results in symptom relief for the conditions this drug is commonly prescribed for.

How to Take It

Follow the directions for using this medicine provided by your doctor. This medicine should be taken with a full glass of water. Continue to take this medicine even if you feel well. Do not miss any doses.

Side Effects

Side effects that may occur while taking this medicine include:

  • weight gain
  • trouble with sleeping
  • headache
  • blurred vision
  • drowsiness
  • dry mouth
  • lightheadedness
  • dizziness
  • increased sensitivity of the skin to sun

Contact your doctor immediately if you experience:

  • high or low blood pressure
  • shuffling walk
  • severe constipation
  • uncontrolled chewing movements
  • difficult urination
  • loss of bladder control
  • high fever
  • difficulty speaking
  • muscle spasms/cramping
  • puffing of the cheeks
  • increased sweating

Warnings & Precautions

  • This medicine may cause drowsiness, dizziness or lightheadedness. Driving and operating machinery is not recommended until you know how you react to it.
  • You may experience dry mouth, constipation, weight gain, or blurry vision while taking Loxitane. Let your doctor know if these symptoms persist or worsen.
  • You may experience nervous system/muscle problems while taking this medication. Your doctor may prescribe another drug to reduce these side effects.
  • Taking loxapine long term can cause a potentially irreversible movement disorder. If you experience uncontrollable movements of your tongue, eyes, lips, face, arms, or legs, contact your healthcare provider immediately.
  • Alcoholic beverages can increase the effects of this medicine and should be avoided.
  • For an overdose, seek medical attention immediately. For non-emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

Before taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. This includes supplements and herbal products.

Dosage & Missed Dose

Follow your doctor’s instructions exactly. Your dosage may occasionally change to ensure the best results.

If you skip a dose, take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses or take extra medicine to make up for the missed dose.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (preferably not in the bathroom). Throw away any medication that is outdated or no longer needed.


If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using this medicine during pregnancy. It is NOT known if this medicine is excreted in breast milk.

More Information

For more information, talk to your doctor, pharmacist or health care provider, or you can visit this website, for additional information from the manufacturer of this drug.



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APA Reference
Psych Central. (2018). Loxitane. Psych Central. Retrieved on October 1, 2020, from


Scientifically Reviewed
Last updated: 8 Oct 2018
Last reviewed: By Christine Traxler, M.D.
Published on All rights reserved.