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Generic Name: Paliperidone (pal-ee-PER-i-done)

Drug Class: Antipsychotics

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Invega (Paliperidone)Invega (Paliperidone)






Invega (paliperidone) is an antipsychotic medicine used to treat certain mood and mental disorders, including schizophrenia. It may decrease hallucinations and help promote clear and positive thinking. It may also help you to feel less agitated and take an active role in everyday life.

This medication is for use in adults and teenagers who are at least 12 years old.

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.

It works by helping change certain chemicals in the brain, which professionals refer to as “neurotransmitters.” It is not yet well-understood why changing these neurochemicals results in symptom relief for the conditions this drug is commonly prescribed for.

How to Take It

Follow the directions for using this medicine provided by your doctor. This medicine may be taken on an empty stomach or with food. Continue to take this medicine even if you feel well. Do not miss any doses.

Side Effects

Side effects that may occur while taking this medicine include:

  • nervousness
  • heartburn
  • tiredness
  • sour stomach
  • abdominal pain
  • drooling
  • swollen tongue
  • headache
  • weight gain
  • difficulty having a bowel movement

Contact your doctor immediately if you experience:

  • loss of balance control
  • difficulty swallowing
  • pain in the arms or legs
  • signs of infection
  • restlessness
  • fainting
  • twisting movements of the body
  • cold sweats
  • muscle spasms
  • tremors
  • dizziness
  • slowed movements

Warnings & Precautions

  • Invega may impair reactions and thinking. Use caution when driving or doing activities that require you to be alert.
  • This medication may cause heart failure in the elderly with dementia-related conditions.
  • You may develop neuroleptic malignant syndrome (NMS) while taking this medication. If you experience severe confusion, dark urine or change in urine output, fever, muscle stiffness, severe tiredness, sweating, or rapid heartbeat, call your doctor immediately.
  • Tell your doctor of any medical conditions you might have, including cataracts, cystic fibrosis, low white blood cell count, high cholesterol, and liver or kidney disease.
  • Your blood sugar may rise while taking Invega. Tell your doctor if you experience increased thirst and urination. Check your blood levels regularly if you have diabetes while taking this medication.
  • You may develop tardive dyskinesia while taking this medication (rare). Call your doctor immediately if you experience any unusual/uncontrolled movements of the lips, mouth, face, tongue, legs, or arms.
  • For an overdose, seek medical attention immediately. For non-emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

Before taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. This includes supplements and herbal products.

Dosage & Missed Dose

Invega is available in extended-release tablet form. It is taken by mouth once, at the same time each day, with or without food.

If you skip a dose, take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses or take extra medicine to make up for the missed dose.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (preferably not in the bathroom). Throw away any medication that is outdated or no longer needed.


Taking this medicine during the last 3 months of pregnancy may cause problems in a newborn baby. However, you may have withdrawal symptoms or other problems if you stop taking Invega during pregnancy. If you become pregnant while taking this medicine, do not stop taking it before consulting your doctor.

DO NOT breast-feed while using this medicine.

More Information

For more information, talk to your doctor, pharmacist or health care provider, or you can visit this website, for additional information from the manufacturer of this drug.



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APA Reference
Psych Central. (2018). Invega. Psych Central. Retrieved on November 29, 2020, from


Scientifically Reviewed
Last updated: 8 Oct 2018
Last reviewed: By Christine Traxler, M.D.
Published on All rights reserved.