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Generic Name: Methylphenidate (METH il FEN i date)

Drug Class: Drug Class: CNS Stimulant

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Daytrana (Methylphenidate) is a transdermal patch, used to treat attention deficit hyperactivity disorder (ADHD) in adults and in children (6 years old and older). It is a central nervous system (CNS) stimulant medication. It works by increasing ability to stay focused and pay attention, as well as controlling behavior problems. It may also improve listening skills.

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.

It works by helping change certain chemicals in the brain, which professionals refer to as “neurotransmitters.” It is not yet well-understood why changing these neurochemicals results in symptom relief for the conditions this drug is commonly prescribed for.

How to Take It

Follow the directions for using this medicine provided by your doctor.

Apply patch to the skin once a day, 2 hours before you need the effects of this drug (usually in the morning). Patch should be removed as directed by your doctor, usually 9 hours later. Using Daytrana later in the day may cause insomnia.

Remove patch from pouch and apply to a clean and dry area on your hip. When properly applied, the patch should stay on while swimming or bathing. When applying a new patch the following day, switch to the other hip.

Do not wear a patch longer than 9 hours per day, even if you apply a new patch to replace one that has fallen off. Use the dosing schedule provided to track your patch wearing time.

Do not cut or divide this medication. Take this medicine regularly, do not skip doses.

Side Effects

Side effects that may occur while taking this medicine include:

  • loss of appetite / weight loss
  • mood swings
  • irritability
  • nervousness
  • nausea
  • blue fingers/toes
  • stuffy nose
  • sleep problems, e.g., insomnia
  • mild skin irritation or redness, bumps where patch was worn

Contact your doctor immediately if you experience:

  • new or worsening symptoms such as mood swings, aggression, hostility, or changes in personality or behavior
  • tics / muscle twitches
  • redness, swelling, or blistering where the skin patch was worn (may also spread to other areas)
  • vision problems
  • unusual sweating
  • chest pain, fast or slow heart rate, pounding heartbeats or fluttering in your chest, feeling like you might pass out
  • numbness, pain, unexplained wounds, cold feeling, or skin color changes (pale, red, or blue appearance) in your fingers or toes
  • seizures

Warnings & Precautions

  • Your blood pressure may be elevated while on this drug. Regularly check your blood pressure and tell your doctor if the results are high.
  • Males may experience a prolonged, painful erection lasting 4 or more hours while using this medication. Contact your doctor immediately if this occurs.
  • Contact your doctor immediately if you experience symptoms of a heart attack (seizure, jaw / chest / left arm pain, shortness of breath, unusual sweating, fainting), symptoms of a stroke (sudden vision changes, body weakness on one side only, slurred speech, confusion).
  • Allergic reactions to this medication are rare; however if you experience difficulty breathing, rash, severe dizziness,  swelling or itching in the facial area / tongue or throat, contact your doctor immediately.
  • The Daytrana patch may cause the skin to lighten / whiten. It may even lighten skin that was not covered by this patch.
  • This medicine may cause drowsiness, dizziness or lightheadedness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to this medicine.
  • For an overdose, seek medical attention immediately. For non emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

Tell your doctor if you have:

high blood pressure;
a history of mental illness or psychosis;
peripheral vascular disease such as Raynaud’s syndrome;
epilepsy or other seizure disorder;
a history of drug or alcohol addiction.

You should not use this medication if you have:

taken an MAOI inhibitor in the past 2 weeks;
a personal or family history of tics (muscle twitches) or Tourette’s syndrome; or
severe anxiety, tension, or agitation (methylphenidate can make these symptoms worse).

Before taking any new prescription or over-the-counter medicine, talk to your doctor or pharmacist. Other medicine can affect the way carbamazepine works in the body.

Dosage & Missed Dose

Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses or take extra medicine to make up for the missed dose.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (preferably not in the bathroom). Throw away any medication that is outdated or no longer needed.


The FDA has assigned Methylphenidate to pregnancy category C. Adequate animal reproductive studies to establish the safe use of methylphenidate during pregnancy have not been conducted.

More Information

For more information, talk to your doctor, pharmacist or health care provider, or you can visit this website, for additional information from the manufacturer of this drug.



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APA Reference
Psych Central. (2018). Daytrana. Psych Central. Retrieved on November 29, 2020, from


Scientifically Reviewed
Last updated: 8 Oct 2018
Last reviewed: By Christine Traxler, M.D.
Published on All rights reserved.