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Generic Name: Amoxapine (a-MOX-a-peen)

Drug Class: Antidepressant, Tricyclic

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Asendin (Amoxapine) is used to treat depression and major depressive disorder. Treating depression can improve mood and sense of well-being. It may also be used to treat anxiety disorders (e.g., panic disorder) and bipolar disorder.Your doctor may prescribe this medicine for other conditions as well.

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.

It works by helping change certain chemicals in the brain, which professionals refer to as “neurotransmitters.” It is not yet well-understood why changing these neurochemicals results in symptom relief for the conditions this drug is commonly prescribed for.

How to Take It

Amoxapine comes as a tablet to take by mouth. It is usually taken one or more times daily. It may be taken with or without food. Take this medicine as directed and do not take more or less of it or more often than prescribed by your doctor. Continue to take this medicine even if you are feeling better. Do not stop taking amoxapine without talking to your doctor, especially if you have taken large doses for a long time. Your doctor will probably will want to decrease your dose slowly.

Side Effects

Side effects that may occur while taking this medicine include:

  • weakness or tiredness
  • drowsiness
  • dizziness
  • dry mouth
  • difficulty urinating
  • headache
  • blurred vision
  • changes in appetite
  • constipation

Contact your doctor immediately if you experience:

  • jaw; neck and back muscle spasms
  • slow or difficult speech
  • change in heartbeat (speeding up, slowing down, irregular)
  • confusion
  • pounding in the ears
  • muscle spasm or jerking of all extremities
  • convulsions
  • weakness on one side of the body
  • difficulty breathing or swallowing
  • severe skin rash
  • sudden loss of consciousness

Warnings & Precautions

  • Do NOT use machinery, drive, or perform activities that require clear vision or alertness until you are sure you can perform such activities safely.
  • Tell your doctor or pharmacist if you have any allergies.
  • Do NOT use amoxapine if you have used an MAO inhibitor such as Furoxone, Marplan, Nardil, Azilect, Eldepryl, Emsam, Zelapar, or Parnate in the last 14 days.
  • Do NOT take amoxapine in larger amounts, or for longer than recommended by your doctor.
  • Do NOT take amoxapine if you have recently had a heart attack.
  • For an overdose, seek medical attention immediately. For non emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

Talk with your physician or pharmacist if you are taking other medications. Avoid drinking alcohol.

Dosage & Missed Dose

Take this medication as prescribed by your doctor.

It may take up to 3 weeks to see improvement in symptoms.

Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses or take extra medicine to make up for the missed dose.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (preferably not in the bathroom). Throw away any medication that is outdated or no longer needed.


If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using this medicine during pregnancy. It is NOT known if this medicine is excreted in breast milk. It is recommended that you DO NOT breast-feed while taking this medicine unless your doctor or pediatrician has told you to.

More Information

For more information, talk to your doctor, pharmacist or health care provider, or you can visit this website, for additional information from the manufacturer of this drug.



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APA Reference
Psych Central. (2018). Asendin. Psych Central. Retrieved on November 30, 2020, from


Scientifically Reviewed
Last updated: 8 Oct 2018
Last reviewed: By Christine Traxler, M.D.
Published on All rights reserved.