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Withdrawal from Antidepressants

Vaughan has a post about a New York Times article over the weekend about a person’s experience with being prescribed an antidepressant. But most of the article describes the process of trying to get off of an antidepressant medication. Specifically, SSRI antidepressants (the most popular type prescribed) often give many people a difficult time when they try to stop taking them:

In 1996, nearly a decade after the introduction of Prozac, its manufacturer, Eli Lilly, sponsored a research symposium to address the increasing number of reports of patients who had difficult symptoms after going off their antidepressants. By then it had become clear that drug-company estimates that at most a few percent of those who took antidepressants would have a hard time getting off were far too low. Jerrold Rosenbaum and Maurizio Fava, researchers at Massachusetts General Hospital, found that among people getting off antidepressants, anywhere from 20 percent to 80 percent (depending on the drug) suffered what was being called antidepressant withdrawal (but which, after the symposium, was renamed “discontinuation syndrome”).

Vaughan also picked up on this change in wording — from withdrawal to “discontinuation syndrome” — which he described as sounding a little too close to something a drug addict would need to do when detoxing.

If up to 80% of people are going to experience these kinds of symptoms (and some medications are more known for them than others), should doctors be warning patients up-front before prescribing the medication? It’s sort of like “informed consent” — I will agree to take this medication if you ensure you tell me everything important about it, including whether it’s difficult or easy to stop taking.

But I know of few doctors who even think about talking to a patient about withdrawal symptoms. Their main focus and concern is helping the person relieve their depressive symptoms. Stopping the medication is the farthest thing from their minds. And yet, it shouldn’t be, given the severity of some of these episodes. Patients should be informed up-front that sometimes these medications may be difficult to get off of. If a person has a choice between two antidepressant medications — for instance, one that’s easier to stop taking than the other — and told of these differences beforehand, it could help the person make an informed choice.

Learn more about discontinuation syndrome here

Withdrawal from Antidepressants

John M. Grohol, Psy.D.

Dr. John Grohol is the founder & CEO of Psych Central. He is an author, researcher and expert in mental health online, and has been writing about online behavior, mental health and psychology issues -- as well as the intersection of technology and human behavior -- since 1992. Dr. Grohol sits on the editorial board of the journal Computers in Human Behavior and is a founding board member and treasurer of the Society for Participatory Medicine. He writes regularly and extensively on mental health concerns, the intersection of technology and psychology, and advocating for greater acceptance of the importance and value of mental health in today's society. You can learn more about Dr. John Grohol here.

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APA Reference
Grohol, J. (2018). Withdrawal from Antidepressants. Psych Central. Retrieved on February 15, 2019, from
Scientifically Reviewed
Last updated: 8 Jul 2018
Last reviewed: By a member of our scientific advisory board on 8 Jul 2018
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