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Bremelanotide Anhedonia

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So I was essentially a normal person mentally before this incident. I was just struggling with libido, ED, and sexual arousal. For this issue I took a small dose of Bremelanotide (PT-141), which is not an FDA approved drug.

While it seemed to increase libido and sexual arousal with my partner, within 2 hours I got intense anhedonia and emotional numbness that I never had before. This caused TONS of anxiety for me. I went to doctors and they said it would subside and it started going away in the first few days but then the apathy/anhedonia/numbness came back in the middle of a day out of nowhere. I’ve never struggled with this in my life. I’m worried I did damage to my brain. I even ended up with ‘blank mind’ and I can no longer socialize with people and my cognitive function is down. I just get up and go through the motions of the day but a lot of the time I feel like staying in bed.

I’m in therapy and it really has not helped. Tried EMDR and its effects are sort of weak. I do not think I am really suffering from a ‘true’ trauma and something physical has gone wrong but docs aren’t sure what. How can I best restore my emotions and pleasure centers? I’m suicidal due to these symptoms. I try to engage in behaviors but its just not the same as before and feels pointless. I can anticipate pleasure and want to engage but I just don’t get the actual pleasure. Doctors have not even been able to give a diagnosis of what I am suffering from. When I asked if this is depression, they say it isn’t ‘classic’ depression.

Is the only way out trying various antidepressant treatments? I’ve heard some of these numb emotions even more though and my problem is I just can’t life anymore even though I have no reason not to.

What went wrong when I took the melanocortin? As far as I know this is not reported anywhere in clinical trials. This is likely why taking research chemicals is very very bad and probably even worse than taking recreational drugs. I want my life back so badly. (From the USA)

Bremelanotide Anhedonia

Answered by on -


  I couldn’t agree with you more about the use of research chemicals prior to FDA approval. The research is still quite inconclusive as this sampling of research articles will show.

My best advice is to talk to an expert on the drug. Perhaps checking in with some of the researchers in the very latest studies listed here. See if they can point you in the direction of a physician who may be able to help.

Wishing you patience and peace,
Dr. Dan
Proof Positive Blog @ PsychCentral

Bremelanotide Anhedonia

Therapists live, online right now, from BetterHelp:

Daniel J. Tomasulo, PhD, TEP, MFA, MAPP

Dan Tomasulo Ph.D., TEP, MFA, MAPP teaches Positive Psychology in the graduate program of Counseling and Clinical Psychology at Columbia University, Teachers College and works with Martin Seligman, the Father of Positive Psychology in the Masters of Applied Positive Psychology (MAPP) program at the University of Pennsylvania. He is Director of the New York Certification in Positive Psychology for the Open Center in New York City and on faculty at New Jersey City University. Sharecare has honored him as one of the top 10 online influencers on the topic of depression. For more information go to: He also writes for Psych Central's Ask the Therapist column and the Proof Positive blog.

APA Reference
Tomasulo, D. (2018). Bremelanotide Anhedonia. Psych Central. Retrieved on November 24, 2020, from
Scientifically Reviewed
Last updated: 8 May 2018 (Originally: 14 Jan 2018)
Last reviewed: By a member of our scientific advisory board on 8 May 2018
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